Ldl cholesterol esterase (Che) from Burkholderia stabilis (BsChe) is a homolog of well-characterized and industrially related bacterial triacylglycerol lipases (Lips). BsChe is a uncommon bacterial Lip enzyme that displays sensible Che exercise and is at the moment utilized in scientific purposes to find out complete serum levels of cholesterol. To analyze the sterol specificity of BsChe, we decided the X-ray construction of BsChe. We found a neighborhood structural change within the active-site cleft, which is perhaps associated to substrate binding and product launch.
We additionally carried out molecular docking research by utilizing the X-ray fashions of BsChe and ldl cholesterol linoleate (CLL), probably the most favorable substrate for BsChe. The outcomes confirmed that the sterol moieties of affordable CLL docking poses localized to a particular active-site cleft floor shaped by Leu266 and Ile287, that are unconserved amongst Burkholderia Lip homologs. Web site-directed mutagenesis recognized these residues as important for the Che exercise of BsChe, and Leu or Ile substitution conferred marked Che exercise to Burkholderia Lips.
Specifically, Burkholderia cepacia and Burkholderia ubonensis Lips with the V266L/L287I double mutation exhibited ~50-fold and 500-fold increased Che actions than these of the wild-type enzymes, respectively. These outcomes present new insights into the substrate-binding mechanisms and selectivities of bacterial Lips.
Pyronaridine: An replace of its pharmacological actions and mechanisms of motion
Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial exercise towards multidrug-resistant Plasmodium. The drug is utilized in mixture with artesunate for the therapy of uncomplicated P. falciparum malaria, in adults and youngsters. The current evaluate briefly retraces the invention of PYR and up to date antimalarial research which has led to the approval of PYR/artesunate mixture (Pyramax) by the European Medicines Company to deal with uncomplicated malaria worldwide. PYR additionally presents a marked antitumor exercise and has revealed efficacy for the therapy of different parasitic ailments (notably Babesia and Trypanosoma infections) and to mitigate the Ebola virus propagation. On the one hand, PYR capabilities has an inhibitor of hemozoin (biomineral malaria pigment, by-product of hemoglobin digestion) formation, blocking the biopolymerization of β-hematin and thus facilitating the buildup of poisonous hematin into the digestive vacuole of the parasite.
Then again, PYR is a bona fide DNA-intercalating agent and an inhibitor of DNA topoisomerase 2, resulting in DNA damages and cell loss of life. Inhibition of hematin polymerization represents the prime mechanism on the origin of the antimalarial exercise, whereas anticancer results depends primarily on the interference with DNA metabolism, as with structurally associated anticancer medicine like amsacrine and quinacrine. As well as, latest research level to an immune modulatory exercise of PYR and the implication of a mitochondrial oxidative pathway. An analogy with the mechanism of motion of artemisinin medicine is underlined. Briefly, the organic actions of pyronaridine are recapitulated to make clear the various well being advantages of this unsung drug. On account of QSAR modeling, we formulated the suggestions concerning physico-chemical traits for promising compounds energetic towards Musca domestica and Mythimna separata.
Homology fashions have been efficiently constructed for each species and molecular docking of QSAR hits vs identified pesticides allowed us to prioritize twenty-two compounds towards Musca domestica and 6 towards Mythimna separata. Our outcomes counsel that pimarane diterpenes, abietanes diterpenes, dimeric diterpenes and scopadulane diterpenes obtained from aerial elements of species of the genus Calceolaria (Calceolariaceae: Scrophulariaceae) may be thought-about as potential insecticidal.
Bacterial triacylglycerol lipase is a potential cholesterol esterase: Identification of a key determinant for sterol-binding specificity
Built-in air cathode microbial gas cell-aerobic bioreactor set-up for enhanced bioelectrodegradation of azo dye Acid Blue 29
On this research, an azo dye (Acid Blue 29 or AB29) was effectively degraded with acetate as co-substrate into much less contaminated biodegraded merchandise utilizing an built-in single chamber microbial gas cell (SMFC)-aerobic bioreactor set-up. The decolorization efficiencies have been various from 91 ± 2% to 94 ± 1.9% and greater than 85% of chemical oxygen demand (COD) removing was achieved for all dye concentrations after totally different working time. The best coulombic effectivity (CE) and cell potential have been 3.18 ± 0.45% and 287.2 mV, respectively, for SMFC treating 100 mg L-1 of AB29. Electrochemical impedance spectroscopy (EIS) revealed that the anode resistance was 0.
Three Ω representing a completely grown biofilm on the anode floor resulted in increased electron switch fee. Fuel chromatography coupled mass spectrometry (GC-MS) investigation demonstrated that originally biodegradation of AB29 began with the cleavage of the azo bond (-N=N-), resulted the biotransformation into fragrant amines. In successive cardio therapy stage, these amines have been biodegraded into decrease molecular weight compounds. The 16S rRNA microbial neighborhood evaluation indicated that at phylum stage, each inoculum and dye acclimated cultures have been primarily consisting of Proteobacteria which was 27.9, 53.6 and 68.9% in inoculum, suspension and anodic biofilm, respectively. At genus stage, each suspension and biofilm contained decolorization in addition to electrochemically energetic micro organism. The outcomes exhibited that the AB29 decolorization would contest with electrogenic micro organism for electrons.
Boric acid |
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| GE4425-1KG | Glentham Life Sciences | 1 kg | EUR 46 |
Boric acid |
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| GE4425-250G | Glentham Life Sciences | 250 g | EUR 40 |
Boric acid |
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| GE4425-500G | Glentham Life Sciences | 500 g | EUR 42 |
Boric acid |
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| GE4425-5KG | Glentham Life Sciences | 5 kg | EUR 90 |
Boric acid |
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| BB0044 | Bio Basic | 500g | EUR 63.92 |
Boric acid |
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| abx082355-500g | Abbexa | 500 g | EUR 203 |
Boric acid |
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| abx082375-500g | Abbexa | 500 g | EUR 189 |
Boric acid |
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| B7305-500000 | ApexBio | 500 g | EUR 125 |
Sucrose, GlenBiol, suitable for molecular biology |
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| GC3201-1KG | Glentham Life Sciences | 1 kg | EUR 75 |
500ML Boric Acid |
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| NAT1088 | National Diagnostics | 500ML | EUR 86 |
Boric acid tablets |
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| 09-0101-100 | Medicago | 100 tablets | EUR 85 |
Boric acid tablets |
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| 09-0101-1000 | Medicago | 1000 tablets | EUR 239 |
BCIP (Molecular Biology Grade) |
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| CE108 | GeneOn | 250 mg | EUR 63 |
BCIP (Molecular Biology Grade) |
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| CE109 | GeneOn | 1 g | EUR 90 |
CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | EUR 55 |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 131 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 410 |
DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 60 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 133 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 319 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 55 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 92 |
DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 78 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 111 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 203 |
Glycine (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 70 |
Glycine (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 190 |
HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 82 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 224 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 354 |
Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 59 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 206 |
NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 60 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 138 |
NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 103 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 300 |
Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 89 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 128 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 446 |
Tween20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 89 |
Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 52 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 56 |
Water, Ultrapure Molecular Biology Grade |
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| 41024-4L | Biotium | 4L | EUR 121 |
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Description: Minimum order quantity: 1 unit of 4L |
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Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 46 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE106 | GeneOn | 1 kg | EUR 60 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE107 | GeneOn | 5 kg | EUR 128 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 79 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 216 |
Formamide deionized (Molecular Biology Grade) |
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| CE145 | GeneOn | 500 ml | EUR 73 |
Formamide deionized (Molecular Biology Grade) |
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| CE146 | GeneOn | 1 l | EUR 100 |
Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 78 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE155 | GeneOn | 500 ml | EUR 65 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE156 | GeneOn | 1 l | EUR 85 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE157 | GeneOn | 2.5 l | EUR 142 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE160 | GeneOn | 100 g | EUR 78 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE161 | GeneOn | 250 g | EUR 128 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE162 | GeneOn | 500 g | EUR 194 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE163 | GeneOn | 1 kg | EUR 294 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE164 | GeneOn | 100 g | EUR 72 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE165 | GeneOn | 500 g | EUR 160 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 256 |
Urea Crystalline (Molecular Biology Grade) |
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| CE167 | GeneOn | 1 kg | EUR 60 |
Urea Crystalline (Molecular Biology Grade) |
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| CE168 | GeneOn | 5 kg | EUR 151 |
MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 85 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 141 |
Sodium chloride (Molecular Biology Grade) |
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| CE205 | GeneOn | 500 g | EUR 52 |
Sodium chloride (Molecular Biology Grade) |
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| CE206 | GeneOn | 1 kg | EUR 59 |
Sodium chloride (Molecular Biology Grade) |
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| CE207 | GeneOn | 5 kg | EUR 103 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE224 | GeneOn | 500 g | EUR 56 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE225 | GeneOn | 1 kg | EUR 70 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE226 | GeneOn | 5 kg | EUR 173 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 83 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 120 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 186 |
TritonX-100 (Molecular Biology Grade) |
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| CE240 | GeneOn | 500 ml | EUR 56 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 66 |
Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 72 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 111 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 134 |
Agarose, low EEO, GlenBiol, suitable for molecular biology |
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| GE6258-100G | Glentham Life Sciences | 100 g | EUR 181 |
Water, distilled, GlenBiol™, suitable for molecular biology |
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| GK8512-1L | Glentham Life Sciences | 1 l | EUR 77 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE135 | GeneOn | 250 g | EUR 60 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE136 | GeneOn | 500 g | EUR 72 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE137 | GeneOn | 1 kg | EUR 104 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE138 | GeneOn | 5 kg | EUR 349 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE148 | GeneOn | 500 g | EUR 56 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE149 | GeneOn | 1 kg | EUR 63 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE150 | GeneOn | 5 kg | EUR 150 |
Yeast extract powder (Molecular Biology Grade) |
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| CE169 | GeneOn | 500 g | EUR 111 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE174 | GeneOn | 1 g | EUR 194 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE175 | GeneOn | 5 g | EUR 767 |
Magnesium acetate - Tetrahydrate (Molecular Biology Grade) |
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| CE190 | GeneOn | 500 g | EUR 82 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE198 | GeneOn | 1 g | EUR 76 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE199 | GeneOn | 5 g | EUR 204 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE200 | GeneOn | 250 mg | EUR 77 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE201 | GeneOn | 1 g | EUR 159 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE202 | GeneOn | 25 mg | EUR 59 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE203 | GeneOn | 100 mg | EUR 105 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE204 | GeneOn | 500 mg | EUR 312 |
SSC Buffer (20X) (Molecular Biology Grade) |
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| CE229 | GeneOn | 1 l | EUR 72 |
XTT sodium salt (Molecular Biology Grade) |
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| CE250 | GeneOn | 100 mg | EUR 174 |
XTT sodium salt (Molecular Biology Grade) |
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| CE251 | GeneOn | 500 mg | EUR 510 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE100 | GeneOn | 50 g | EUR 107 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE101 | GeneOn | 100 g | EUR 161 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE102 | GeneOn | 250 g | EUR 323 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE103 | GeneOn | 500 g | EUR 547 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE104 | GeneOn | 1 kg | EUR 969 |
Agarose LE, Ultra-Pure Molecular Biology Grade, 100 g |
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| 41028-100G | Biotium | 100G | EUR 222 |
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Description: Minimum order quantity: 1 unit of 100G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 25 g |
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| 41028-25G | Biotium | 25G | EUR 109 |
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Description: Minimum order quantity: 1 unit of 25G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 500 g |
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| 41028-500G | Biotium | 500G | EUR 719 |
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Description: Minimum order quantity: 1 unit of 500G |
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EDTA solution pH 8.0 (0.5 M) (Molecular Biology Grade) |
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| CE141 | GeneOn | 500 ml | EUR 73 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE178 | GeneOn | 500 g | EUR 91 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE179 | GeneOn | 2.5 kg | EUR 251 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE180 | GeneOn | 500 g | EUR 87 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE181 | GeneOn | 2.5 kg | EUR 246 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE182 | GeneOn | 500 g | EUR 90 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE183 | GeneOn | 2.5 kg | EUR 251 |
LB-Medium - Powder according to Miller (Molecular Biology Grade) |
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| CE184 | GeneOn | 2.5 kg | EUR 246 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT |
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| AGR-LE-100 | CORNING | 1/pk | EUR 168 |
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Description: Bioscience Mol Bio; Agarose |
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100 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CI | CORNING | 100 mL/pk | EUR 57 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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1 L, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CM | CORNING | 1L/pk | EUR 98 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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500 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CV | CORNING | 500 mL/pk | EUR 106 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 500G/UNIT, 10 UNITS PER CASE |
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| AGR-LE-5001 | CORNING | 1/pk | EUR 3058 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE MS, PCR SCREENING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE |
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| AGR-MS-1001 | CORNING | 1/pk | EUR 2038 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT, 10 UNITS PER CASE |
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| AGR-LE-1001 | CORNING | 1/pk | EUR 772 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE (AL) |
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| AGR-LM-1001 | CORNING | 1/pk | EUR 3737 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 50G/UNIT, 10 UNITS PER CASE (AL) |
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| AGR-LM-501 | CORNING | 1/pk | EUR 2075 |
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Description: Bioscience Mol Bio; Agarose |
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30UL CLEAR PIPET TIPS FOR MOLECULAR DEVICE LIBERTY. |
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| LT-384-R | CORNING | 3840/pk | EUR 2193 |
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Description: Robotic Tips; Robotic tips - Axygen |
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Agarose, Molecular Grade |
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| BIO-41025 | Bioline | 500g | Ask for price |
Agarose, Molecular Grade |
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| BIO-41026 | Bioline | 100g | Ask for price |
Molecular Weight Marker |
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| abx098957-15ul | Abbexa | 15 ul | EUR 105 |
Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column |
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| FAPDE-holder-for-ion-exchange | Favorgen | 1 prep | EUR 158 |
ELISA kit for Human LMWK (Low Molecular Weight Kininogen) |
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| ELK1799 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
Description: A sandwich ELISA kit for detection of Low Molecular Weight Kininogen from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Human HMWK (High Molecular Weight Kininogen) |
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| ELK2201 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
Description: A sandwich ELISA kit for detection of High Molecular Weight Kininogen from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Mouse HMWK (High Molecular Weight Kininogen) |
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| ELK7788 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
|
Description: A sandwich ELISA kit for detection of High Molecular Weight Kininogen from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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DiscoveryProbe? Cancer Biology-related Compounds Panel |
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| L1003-5 | ApexBio | 5 mg/well | EUR 3947 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to cancer biology, including p53, EGFR and PKC etc. Facilitate your research towards the insights of gene regulation, tumorgenesis and immunotherapy etc. |
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Pesticides are used to manage and fight bugs and pests within the agricultural sector, households, and public well being packages. The frequent and disorderly use of those pesticides might result in number of undesired results. Due to this fact, pure merchandise have many benefits over to artificial compounds for use as pesticides. The aim of this research was to seek out pure merchandise with insecticidal potential towards Musca domestica and Mythimna separata. To attain this aim, we developed predictive QSAR fashions utilizing MuDRA, PLS, and RF approaches and carried out digital screening of 117 pure merchandise.