Background and goal: Pectobacterium carotovorum subsp. carotovorum is a plant-pathogenic bacterium. It’s a post-harvest pathogen and causes tender rot ailments in contaminated crops. Completely different virulent bacteriophages have been remoted from completely different areas on the planet. These bacteriophages have been tolerant to excessive concentrations of calcium chloride and magnesium chloride. Whereas, the excessive concentrations of zinc chloride and aluminum chloride decreased the exercise and stability of phages. Subsequently, the current analysis aimed to review the biology of P. carotovorum phage (Pc1) through the use of a one-step development experiment, its stability to completely different concentrations of some chemical substances and molecular traits of this phage isolate.
Supplies and strategies: One step development experiment, chemical stability, and molecular traits through the use of RAPD-PCR of P. carotovorum phage (Pc1) have been studied.
Outcomes: The P. carotovorum phage (Pc1) isolate was discovered to have a latent interval of 20 min and its burst measurement is about 92 pfu cell-1. Calcium chloride, magnesium chloride, and copper sulphate (from 0.1-0.5 mM) elevated the infectivity of Pc1 phage, whereas, zinc chloride in the identical concentrations lowered its infectivity. RAPD-PCR amplification was indicated that the full amplified merchandise have been 32 bands with measurement ranged from 0.179-2.365 Kbp.
Conclusion: Since, zinc chloride (at concentrations of 0.1-0.5 mM) lowered infectivity of Pc1 phage isolate, subsequently, any chemical compounds containing zinc have to be averted in designing biocontrol technique through the use of phages towards tender rot bacterium (P. carotovorum) in potatoes.
Hyper-truncated Asn355- and Asn391-glycans modulate the exercise of neutrophil granule myeloperoxidase
Myeloperoxidase (MPO) performs important roles in neutrophil-mediated immunity through the era of reactive oxidation merchandise. Complicated carbohydrates embellish MPO at discrete websites, however their purposeful relevance stay elusive. To this finish, we’ve got characterised the structure-biosynthesis-activity relationship of neutrophil MPO (nMPO). Mass spectrometry demonstrated that nMPO carries each attribute under-processed and hyper-truncated glycans.
Occlusion of the Asn355/Asn391-glycosylation websites and the Asn323-/Asn483-glycans, situated within the MPO dimerisation zone, was discovered to have an effect on the native glycan processing, thereby offering a molecular foundation of the site-specific nMPO glycosylation. Native mass spectrometry, mass photometry, and glycopeptide profiling revealed vital molecular complexity of diprotomeric nMPO arising from heterogeneous glycosylation, oxidation, chlorination and polypeptide truncation variants, and a beforehand unreported low-abundance monoprotomer. Longitudinal profiling of maturing, mature, granule-separated, and pathogen-stimulated neutrophils demonstrated that nMPO is dynamically expressed throughout granulopoiesis, erratically distributed throughout granules and degranulated upon activation.
We additionally present that proMPO-to-MPO maturation happens throughout early/mid-stage granulopoiesis. Whereas comparable international MPO glycosylation was noticed throughout situations, the conserved Asn355-/Asn391-sites displayed elevated glycan hyper-truncation, which correlated with larger enzyme actions of MPO in distinct granule populations. Enzymatic trimming of the Asn355-/Asn391-glycans recapitulated the exercise acquire and confirmed that nMPO carrying hyper-truncated glycans at these positions reveals elevated thermal stability, polypeptide accessibility, and ceruloplasmin-mediated inhibition potential relative to native nMPO. Lastly, molecular modelling revealed that hyper-truncated Asn355-glycans positioned within the MPO-ceruloplasmin interface are crucial for uninterrupted inhibition. Right here, by means of an modern and complete method, we report novel purposeful roles of MPO glycans, offering new perception into neutrophil-mediated immunity.
Biochemical and Molecular Characteristics of Pc1 Virulent Phage Isolate Infecting Pectobacterium carotovorum
Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo
Ache administration devoid of great opioid hostile results continues to be removed from attain regardless of vigorous analysis and improvement efforts. Alternate options to classical opioids have been hunted for years, and mounting reviews of people discovering ache aid with kratom have just lately intensified analysis on this pure product. Though the composition of kratom is advanced, the pharmacological characterization of its most considerable alkaloids has drawn consideration to a few molecules particularly, owing to their demonstrated antinociceptive exercise and restricted unwanted effects in vivo. These three molecules are mitragynine (MG), its oxidized lively metabolite, 7-hydroxymitragynine (7OH), and the indole-to-spiropseudoindoxy rearrangement product of MG often known as mitragynine pseudoindoxyl (MP).
Though these three alkaloids have been proven to preferentially activate the G protein signaling pathway by binding and allosterically modulating the μ-opioid receptor (MOP), a molecular degree understanding of this course of is missing and but vital for the design of improved therapeutics. The molecular dynamics research and experimental validation reported right here present an atomic degree description of how MG, 7OH, and MP bind and allosterically modulate the MOP, which might finally information structure-based drug design of improved therapeutics.
Molecular sieve 3A, powder (3 Angstrom pore size) |
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| GX5452-1 | Glentham Life Sciences | 1 | EUR 104 |
Molecular sieve 3A, 0.4-0.8 mm beads (3 Angstrom pore size) |
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| GX1358-500 | Glentham Life Sciences | 500 | EUR 95 |
Pyridine, GlenBiol™, suitable for molecular biology with molecular sieve |
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| GS8780-2500 | Glentham Life Sciences | 2500 | EUR 249.8 |
Dessicant cartridge with molecular sieve HI-904 |
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| TIT1062 | Scientific Laboratory Supplies | EACH | EUR 147.6 |
Toluene, GlenDry™, anhydrous over molecular sieve |
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| GS7641-1 | Glentham Life Sciences | 1 | EUR 77.6 |
Toluene, GlenDry™, anhydrous over molecular sieve |
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| GS7641-100 | Glentham Life Sciences | 100 | EUR 56.6 |
Toluene, GlenDry™, anhydrous over molecular sieve |
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| GS7641-2500 | Glentham Life Sciences | 2500 | EUR 144.2 |
Toluene, GlenDry™, anhydrous over molecular sieve |
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| GS7641-500 | Glentham Life Sciences | 500 | EUR 64.7 |
Methanol, GlenDry™, anhydrous over molecular sieve |
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| GS1114-1 | Glentham Life Sciences | 1 | EUR 67.1 |
Methanol, GlenDry™, anhydrous over molecular sieve |
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| GS1114-100 | Glentham Life Sciences | 100 | EUR 59 |
Methanol, GlenDry™, anhydrous over molecular sieve |
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| GS1114-2500 | Glentham Life Sciences | 2500 | EUR 130 |
Methanol, GlenDry™, anhydrous over molecular sieve |
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| GS1114-500 | Glentham Life Sciences | 500 | EUR 62.7 |
Pyridine, GlenDry™, anhydrous over molecular sieve |
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| GS9957-1 | Glentham Life Sciences | 1 | EUR 204.1 |
Pyridine, GlenDry™, anhydrous over molecular sieve |
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| GS9957-100 | Glentham Life Sciences | 100 | EUR 64.7 |
Pyridine, GlenDry™, anhydrous over molecular sieve |
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| GS9957-2500 | Glentham Life Sciences | 2500 | EUR 375.2 |
Pyridine, GlenDry™, anhydrous over molecular sieve |
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| GS9957-500 | Glentham Life Sciences | 500 | EUR 143.2 |
Dimethylformamide, GlenBiol™, suitable for molecular biology with molecular sieve |
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| GS3406-2500 | Glentham Life Sciences | 2500 | EUR 116.2 |
Molecular sieve 13X, powder (8.5 Angstrom pore size) |
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| GX1569-500 | Glentham Life Sciences | 500 | EUR 102.4 |
Cyclohexane, GlenDry™, anhydrous over molecular sieve |
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| GS5141-1 | Glentham Life Sciences | 1 | EUR 110.7 |
Cyclohexane, GlenDry™, anhydrous over molecular sieve |
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| GS5141-100 | Glentham Life Sciences | 100 | EUR 80.4 |
Cyclohexane, GlenDry™, anhydrous over molecular sieve |
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| GS5141-2500 | Glentham Life Sciences | 2500 | EUR 205.3 |
Cyclohexane, GlenDry™, anhydrous over molecular sieve |
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| GS5141-500 | Glentham Life Sciences | 500 | EUR 92.7 |
Acetonitrile, GlenDry™, anhydrous over molecular sieve |
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| GS0555-1 | Glentham Life Sciences | 1 | EUR 86.5 |
Acetonitrile, GlenDry™, anhydrous over molecular sieve |
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| GS0555-100 | Glentham Life Sciences | 100 | EUR 58 |
Acetonitrile, GlenDry™, anhydrous over molecular sieve |
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| GS0555-2500 | Glentham Life Sciences | 2500 | EUR 168.7 |
Acetonitrile, GlenDry™, anhydrous over molecular sieve |
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| GS0555-500 | Glentham Life Sciences | 500 | EUR 69 |
1,4-Dioxan, GlenDry™, anhydrous over molecular sieve |
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| GS3872-1 | Glentham Life Sciences | 1 | EUR 120.8 |
1,4-Dioxan, GlenDry™, anhydrous over molecular sieve |
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| GS3872-100 | Glentham Life Sciences | 100 | EUR 75.7 |
1,4-Dioxan, GlenDry™, anhydrous over molecular sieve |
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| GS3872-2500 | Glentham Life Sciences | 2500 | EUR 234.8 |
1,4-Dioxan, GlenDry™, anhydrous over molecular sieve |
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| GS3872-500 | Glentham Life Sciences | 500 | EUR 93.1 |
Triethylamine, GlenDry™, anhydrous over molecular sieve |
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| GS4732-1 | Glentham Life Sciences | 1 | EUR 484.3 |
Triethylamine, GlenDry™, anhydrous over molecular sieve |
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| GS4732-100 | Glentham Life Sciences | 100 | EUR 109.4 |
Triethylamine, GlenDry™, anhydrous over molecular sieve |
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| GS4732-500 | Glentham Life Sciences | 500 | EUR 341.4 |
Tetrahydrofuran, GlenDry™, anhydrous over molecular sieve |
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| GS8667-1 | Glentham Life Sciences | 1 | EUR 128.4 |
Tetrahydrofuran, GlenDry™, anhydrous over molecular sieve |
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| GS8667-100 | Glentham Life Sciences | 100 | EUR 86.5 |
Tetrahydrofuran, GlenDry™, anhydrous over molecular sieve |
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| GS8667-2500 | Glentham Life Sciences | 2500 | EUR 246.9 |
Tetrahydrofuran, GlenDry™, anhydrous over molecular sieve |
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| GS8667-500 | Glentham Life Sciences | 500 | EUR 104.1 |
Ethyl Acetate, GlenDry™, anhydrous over molecular sieve |
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| GS4125-1 | Glentham Life Sciences | 1 | EUR 103.6 |
Ethyl Acetate, GlenDry™, anhydrous over molecular sieve |
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| GS4125-100 | Glentham Life Sciences | 100 | EUR 75.7 |
Ethyl Acetate, GlenDry™, anhydrous over molecular sieve |
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| GS4125-2500 | Glentham Life Sciences | 2500 | EUR 191.7 |
Ethyl Acetate, GlenDry™, anhydrous over molecular sieve |
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| GS4125-500 | Glentham Life Sciences | 500 | EUR 86.5 |
1,2-Dimethoxyethane, GlenDry, anhydrous over molecular sieve |
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| GS5227-1 | Glentham Life Sciences | 1 | EUR 164.5 |
1,2-Dimethoxyethane, GlenDry, anhydrous over molecular sieve |
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| GS5227-100 | Glentham Life Sciences | 100 | EUR 62.7 |
1,2-Dimethoxyethane, GlenDry, anhydrous over molecular sieve |
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| GS5227-2500 | Glentham Life Sciences | 2500 | EUR 309.4 |
1,2-Dimethoxyethane, GlenDry, anhydrous over molecular sieve |
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| GS5227-500 | Glentham Life Sciences | 500 | EUR 118.2 |
Dimethylformamide, GlenDry™, anhydrous over molecular sieve |
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| GS4658-1 | Glentham Life Sciences | 1 | EUR 120.7 |
Dimethylformamide, GlenDry™, anhydrous over molecular sieve |
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| GS4658-100 | Glentham Life Sciences | 100 | EUR 66.8 |
Dimethylformamide, GlenDry™, anhydrous over molecular sieve |
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| GS4658-2500 | Glentham Life Sciences | 2500 | EUR 244.3 |
Dimethylformamide, GlenDry™, anhydrous over molecular sieve |
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| GS4658-500 | Glentham Life Sciences | 500 | EUR 88.6 |
n-Hexane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS8756-1 | Glentham Life Sciences | 1 | EUR 126.7 |
n-Hexane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS8756-100 | Glentham Life Sciences | 100 | EUR 91.6 |
n-Hexane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS8756-2500 | Glentham Life Sciences | 2500 | EUR 236.3 |
n-Hexane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS8756-500 | Glentham Life Sciences | 500 | EUR 104.9 |
n-Heptane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS0594-1 | Glentham Life Sciences | 1 | EUR 114 |
n-Heptane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS0594-100 | Glentham Life Sciences | 100 | EUR 80.4 |
n-Heptane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS0594-2500 | Glentham Life Sciences | 2500 | EUR 221.8 |
n-Heptane 95%, GlenDry™, anhydrous over molecular sieve |
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| GS0594-500 | Glentham Life Sciences | 500 | EUR 94.1 |
Propan-2-ol, GlenDry™, anhydrous over molecular sieve |
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| GS1309-1 | Glentham Life Sciences | 1 | EUR 88.9 |
Propan-2-ol, GlenDry™, anhydrous over molecular sieve |
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| GS1309-100 | Glentham Life Sciences | 100 | EUR 64.3 |
Propan-2-ol, GlenDry™, anhydrous over molecular sieve |
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| GS1309-2500 | Glentham Life Sciences | 2500 | EUR 165.5 |
Propan-2-ol, GlenDry™, anhydrous over molecular sieve |
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| GS1309-500 | Glentham Life Sciences | 500 | EUR 75.3 |
Molecular sieve 5A, 3-5 mm beads (5 Angstrom pore size) |
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| GX4420-500 | Glentham Life Sciences | 500 | EUR 114.5 |
Molecular sieve 5A, 1.6 - 2.5 mm beads (5 Angstrom pore size) |
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| GX7192-500 | Glentham Life Sciences | 500 | EUR 114.5 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX7674-1 | Glentham Life Sciences | 1 | EUR 134.1 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX7674-500 | Glentham Life Sciences | 500 | EUR 104 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX7863-1 | Glentham Life Sciences | 1 | EUR 131.1 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX7863-500 | Glentham Life Sciences | 500 | EUR 111.5 |
Molecular sieve 4A, 2-3 mm beads (4 Angstrom pore size) |
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| GX8202-500 | Glentham Life Sciences | 500 | EUR 111.5 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX2780-1 | Glentham Life Sciences | 1 | EUR 114.5 |
Molecular sieve 4A, 3-5 mm beads (4 Angstrom pore size) |
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| GX2780-500 | Glentham Life Sciences | 500 | EUR 95 |
Molecular sieve 13X, 3-5 mm beads (8.5 Angstrom pore size) |
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| GX7122-5 | Glentham Life Sciences | 5 | EUR 342.2 |
Molecular sieve 13X, 3-5 mm beads (8.5 Angstrom pore size) |
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| GX7122-500 | Glentham Life Sciences | 500 | EUR 98 |
Molecular sieve 13X, 0.4-0.8 mm beads (8.5 Angstrom pore size) |
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| GX8738-500 | Glentham Life Sciences | 500 | EUR 107 |
2,2,4-Trimethylpentane, GlenDry™, anhydrous over molecular sieve |
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| GS9928-1 | Glentham Life Sciences | 1 | EUR 125.5 |
2,2,4-Trimethylpentane, GlenDry™, anhydrous over molecular sieve |
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| GS9928-100 | Glentham Life Sciences | 100 | EUR 86.1 |
2,2,4-Trimethylpentane, GlenDry™, anhydrous over molecular sieve |
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| GS9928-2500 | Glentham Life Sciences | 2500 | EUR 244.8 |
2,2,4-Trimethylpentane, GlenDry™, anhydrous over molecular sieve |
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| GS9928-500 | Glentham Life Sciences | 500 | EUR 103 |
Xylene mixed isomers, GlenDry™, anhydrous over molecular sieve |
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| GS3017-1 | Glentham Life Sciences | 1 | EUR 85 |
Xylene mixed isomers, GlenDry™, anhydrous over molecular sieve |
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| GS3017-100 | Glentham Life Sciences | 100 | EUR 56.6 |
Xylene mixed isomers, GlenDry™, anhydrous over molecular sieve |
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| GS3017-2500 | Glentham Life Sciences | 2500 | EUR 166.5 |
Xylene mixed isomers, GlenDry™, anhydrous over molecular sieve |
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| GS3017-500 | Glentham Life Sciences | 500 | EUR 68.3 |
Molecular sieves 200g |
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| TIT1072 | Scientific Laboratory Supplies | 200G | EUR 711.6 |
bis(2-Methoxyethyl) Ether, GlenDry™, anhydrous over molecular sieve |
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| GS2001-1 | Glentham Life Sciences | 1 | EUR 538.3 |
bis(2-Methoxyethyl) Ether, GlenDry™, anhydrous over molecular sieve |
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| GS2001-100 | Glentham Life Sciences | 100 | EUR 107 |
bis(2-Methoxyethyl) Ether, GlenDry™, anhydrous over molecular sieve |
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| GS2001-500 | Glentham Life Sciences | 500 | EUR 288.3 |
N-Methyl-2-pyrrolidone, GlenDry™, anhydrous over molecular sieve |
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| GS4330-1 | Glentham Life Sciences | 1 | EUR 201.6 |
N-Methyl-2-pyrrolidone, GlenDry™, anhydrous over molecular sieve |
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| GS4330-100 | Glentham Life Sciences | 100 | EUR 63.8 |
N-Methyl-2-pyrrolidone, GlenDry™, anhydrous over molecular sieve |
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| GS4330-2500 | Glentham Life Sciences | 2500 | EUR 370.3 |
N-Methyl-2-pyrrolidone, GlenDry™, anhydrous over molecular sieve |
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| GS4330-500 | Glentham Life Sciences | 500 | EUR 141.3 |
Chloroform, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS1447-1 | Glentham Life Sciences | 1 | EUR 133 |
Chloroform, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS1447-100 | Glentham Life Sciences | 100 | EUR 96.4 |
Chloroform, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS1447-2500 | Glentham Life Sciences | 2500 | EUR 245.9 |
Chloroform, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS1447-500 | Glentham Life Sciences | 500 | EUR 110.8 |
Diethyl Ether, GlenDry™, anhydrous stabilised with BHT over molecular sieve |
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| GS5963-1 | Glentham Life Sciences | 1 | EUR 113.4 |
Diethyl Ether, GlenDry™, anhydrous stabilised with BHT over molecular sieve |
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| GS5963-100 | Glentham Life Sciences | 100 | EUR 56.6 |
Diethyl Ether, GlenDry™, anhydrous stabilised with BHT over molecular sieve |
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| GS5963-2500 | Glentham Life Sciences | 2500 | EUR 231.7 |
Diethyl Ether, GlenDry™, anhydrous stabilised with BHT over molecular sieve |
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| GS5963-500 | Glentham Life Sciences | 500 | EUR 79.4 |
Diethyl Ether, GlenDry™, anhydrous stabilised with ethanol over molecular sieve |
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| GS8536-1 | Glentham Life Sciences | 1 | EUR 108.6 |
Diethyl Ether, GlenDry™, anhydrous stabilised with ethanol over molecular sieve |
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| GS8536-100 | Glentham Life Sciences | 100 | EUR 76 |
Diethyl Ether, GlenDry™, anhydrous stabilised with ethanol over molecular sieve |
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| GS8536-2500 | Glentham Life Sciences | 2500 | EUR 220.9 |
Diethyl Ether, GlenDry™, anhydrous stabilised with ethanol over molecular sieve |
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| GS8536-500 | Glentham Life Sciences | 500 | EUR 88.6 |
Dichloromethane, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS0168-1 | Glentham Life Sciences | 1 | EUR 88.6 |
Dichloromethane, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS0168-100 | Glentham Life Sciences | 100 | EUR 64.3 |
Dichloromethane, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS0168-2500 | Glentham Life Sciences | 2500 | EUR 164.5 |
Dichloromethane, GlenDry™, anhydrous stabilised with amylene over molecular sieve |
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| GS0168-500 | Glentham Life Sciences | 500 | EUR 74.1 |
Bottle top assembly with molecular sieves (HI904) |
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| TIT1060 | Scientific Laboratory Supplies | EACH | EUR 565.2 |
Molecular Weight Marker |
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| abx098957-15ul | Abbexa | 15 ul | EUR 126 |
Agarose, Molecular Grade |
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| BIO-41025 | Bioline | 500g | Ask for price |
Agarose, Molecular Grade |
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| BIO-41026 | Bioline | 100g | Ask for price |
Human Complement 3a (C3a) purified protein |
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| HC3A15-R-25 | Alpha Diagnostics | 25 ug | EUR 416.4 |
NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 72 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 165.6 |
NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 123.6 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 360 |
DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 93.6 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 133.2 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 243.6 |
Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 106.8 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 153.6 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 535.2 |
BCIP (Molecular Biology Grade) |
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| CE108 | GeneOn | 250 mg | EUR 75.6 |
A small assortment of C 2 -symmetry hydroxylated biphenyls derivatives featured with a α,β-unsaturated ketone as lead construction was ready and the aptitude of such compounds to behave as antiproliferative brokers towards 4 human malignant melanoma cell traces was assayed. The prodrug method was utilized to be able to enhance supply of compounds into the cell by modulation of the phenolic-OH protecting group. The hydroxylated biphenyl construction bearing an α,β-unsaturated ketone and a phenolic- O -prenylated chain would facilitated the supply of the molecule and interactions with the organic targets.