Probing the Molecular-Degree Interactions in an Lively Pharmaceutical Ingredient (API) – Polymer Dispersion and the Ensuing Affect on Drug Product Formulation.
- An investigation of underlying mechanisms of API-polymer interplay patterns has the potential to supply helpful insights for choosing applicable formulations with superior bodily stability and processability.
- On this examine, copovidone was used as a polymeric provider for a number of mannequin compounds together with clotrimazole, nifedipine, and posaconazole.
- The numerous chemical constructions conferred the power for the mannequin compounds to type distinct interactions with copovidone.
- Rheology and nuclear magnetic resonance (NMR) have been mixed to analyze the molecular sample and relative power of energetic pharmaceutical ingredient (API)-polymer interactions.
- As well as, the affect of the interactions on formulation processability through sizzling soften extrusion (HME) and bodily stability have been evaluated.The rheological response of an API-polymer system was discovered to be extremely delicate to API-polymer interplay, relying each on API chemistry and API-polymer miscibility.
- Within the techniques studied, dispersed API induced a stronger plasticizer impact on the polymer matrix in comparison with crystalline/aggregated API. Correspondingly, the processing torque through HME confirmed a proportional relationship with the utmost complicated viscosity of the API-polymer system.
- With a purpose to quantitatively consider the relative power of the API-polymer interplay, homogeneously dispersed API-polymer amorphous samples have been ready by HME at an elevated temperature.
- DSC, XRD, and rheology have been employed to substantiate the amorphous integrity and homogeneity of the resultant extrudates. Subsequently, the homogeneously dispersed API-polymer amorphous dispersions have been interrogated by rheology and NMR to supply a qualitative and quantitative evaluation of the character of the API-polymer interplay, each macroscopically and microscopically.
- Rheological grasp curves of frequency sweeps of the extrudates exhibited a robust dependence on the API chemistry and revealed a rank ordering of the relative power of API-copovidone interactions, within the order of posaconazole > nifedipine > clotrimazole.
- NMR information supplied the means to exactly map the API-polymer interplay sample and establish the precise websites of interplay from a molecular perspective. Lastly, the affect of API-polymer interactions on the bodily stability of the resultant extrudates was studied.
- Qualitative and quantitative analysis of the relative power of the API-polymer interplay was efficiently completed by using mixed rheology and NMR. Graphical Summary
allelebio
PSMB8 antibody |
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| 70R-19589 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal PSMB8 antibody |
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PSMB8 Antibody |
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| 1-CSB-PA116429 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
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PSMB8 Antibody |
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| 1-CSB-PA018886GA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
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PSMB8 Antibody |
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| 1-CSB-PA018886LA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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PSMB8 Antibody |
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| 1-CSB-PA775839 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
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PSMB8 Conjugated Antibody |
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| C43134 | SAB | 100ul | EUR 476.4 |
PSMB8 Polyclonal Antibody |
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| A73468 | EpiGentek |
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PSMB8 Antibody, HRP conjugated |
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| 1-CSB-PA018886LB01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
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PSMB8 Antibody, FITC conjugated |
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| 1-CSB-PA018886LC01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
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PSMB8 Antibody, Biotin conjugated |
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| 1-CSB-PA018886LD01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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Monoclonal PSMB8 Antibody, Clone: 1A5 |
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| AMM02864G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E |
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Psmb8/ Rat Psmb8 ELISA Kit |
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| ELI-15652r | Lifescience Market | 96 Tests | EUR 1063.2 |
Proteasome subunit beta type-8 (PSMB8) Antibody |
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| 20-abx211178 | Abbexa |
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Proteasome subunit beta type-8 (PSMB8) Antibody |
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| 20-abx211851 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| 20-abx141396 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| 20-abx114776 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| abx028154-400ul | Abbexa | 400 ul | EUR 627.6 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| abx028154-80l | Abbexa | 80 µl | EUR 343.2 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| 20-abx006453 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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| abx011689-100ul | Abbexa | 100 ul | EUR 493.2 |
Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3 |
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| AMM03954G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E |
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PSMB8 siRNA |
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| 20-abx930156 | Abbexa |
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PSMB8 siRNA |
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| 20-abx930157 | Abbexa |
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PSMB8 siRNA |
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| 20-abx904317 | Abbexa |
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PSMB8 Rabbit pAb |
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| A7340-100ul | Abclonal | 100 ul | EUR 369.6 |
PSMB8 Rabbit pAb |
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| A7340-200ul | Abclonal | 200 ul | EUR 550.8 |
PSMB8 Rabbit pAb |
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| A7340-20ul | Abclonal | 20 ul | EUR 219.6 |
PSMB8 Rabbit pAb |
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| A7340-50ul | Abclonal | 50 ul | EUR 267.6 |
PSMB8 Blocking Peptide |
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| BF0434-BP | Affbiotech | 1mg | EUR 234 |
PSMB8 protein (His tag) |
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| 80R-2608 | Fitzgerald | 100 ug | EUR 386.4 |
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Description: Purified recombinant PSMB8 protein |
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Canine PSMB8 ELISA KIT |
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| ELI-15651d | Lifescience Market | 96 Tests | EUR 1113.6 |
Rat PSMB8 shRNA Plasmid |
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| 20-abx984734 | Abbexa |
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Human PSMB8 shRNA Plasmid |
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| 20-abx953843 | Abbexa |
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Mouse PSMB8 shRNA Plasmid |
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| 20-abx971337 | Abbexa |
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PSMB8 Recombinant Protein (Rat) |
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| RP222629 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Mouse) |
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| RP165287 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Human) |
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| RP085356 | ABM | 100 ug | Ask for price |
Psmb8 ORF Vector (Rat) (pORF) |
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| ORF074211 | ABM | 1.0 ug DNA | EUR 607.2 |
PSMB8 ORF Vector (Human) (pORF) |
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| ORF028453 | ABM | 1.0 ug DNA | EUR 486 |
Psmb8 ORF Vector (Mouse) (pORF) |
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| ORF055097 | ABM | 1.0 ug DNA | EUR 607.2 |
[KO Validated] PSMB8 Rabbit pAb |
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| A19933-100ul | Abclonal | 100 ul | EUR 492 |
[KO Validated] PSMB8 Rabbit pAb |
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| A19933-200ul | Abclonal | 200 ul | EUR 685.2 |
[KO Validated] PSMB8 Rabbit pAb |
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| A19933-20ul | Abclonal | 20 ul | EUR 265.2 |
[KO Validated] PSMB8 Rabbit pAb |
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| A19933-50ul | Abclonal | 50 ul | EUR 344.4 |
PSMB8 ELISA Kit (Dog) (OKEH03975) |
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| OKEH03975 | Aviva Systems Biology | 96 Wells | EUR 1012.8 |
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Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL |
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PSMB8 ELISA Kit (Human) (OKEH07770) |
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| OKEH07770 | Aviva Systems Biology | 96 Wells | EUR 1310.4 |
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Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL |
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PSMB8 ELISA Kit (Human) (OKCD02695) |
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| OKCD02695 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
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Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL |
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Psmb8 sgRNA CRISPR Lentivector set (Rat) |
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| K6921501 | ABM | 3 x 1.0 ug | EUR 406.8 |
PSMB8 sgRNA CRISPR Lentivector set (Human) |
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| K1740301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 sgRNA CRISPR Lentivector set (Mouse) |
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| K4425601 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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| TU167173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR GFP Stable Cell Line |
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| TU069046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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| TU266964 | ABM | 1.0 ml | Ask for price |
PSMB8 Protein Vector (Rat) (pPM-C-HA) |
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| PV296844 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-C-His) |
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| PV296842 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-N-His) |
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| PV296843 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPM-C-His) |
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| PV296845 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPM-C-HA) |
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| PV113812 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPM-C-HA) |
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| PV220388 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPB-C-His) |
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| PV113810 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPB-N-His) |
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| PV113811 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPM-C-His) |
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| PV113813 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPB-C-His) |
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| PV220386 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPB-N-His) |
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| PV220387 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPM-C-His) |
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| PV220389 | ABM | 500 ng | EUR 723.6 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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| TU117173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR Luciferase Stable Cell Line |
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| TU019046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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| TU216964 | ABM | 1.0 ml | Ask for price |
Human Proteasome subunit beta type-8 (PSMB8) |
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| 1-CSB-EP018886HU | Cusabio |
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Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli |
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Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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| K6921502 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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| K6921503 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3) |
|||
| K6921504 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K1740302 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2) |
|||
| K1740303 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3) |
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| K1740304 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
|||
| K4425602 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
|||
| K4425603 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4425604 | ABM | 1.0 ug DNA | EUR 184.8 |
Recombinant Human PSMB8 Protein, His, E.coli-1mg |
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| QP13190-1mg | EnQuireBio | 1mg | EUR 3308.4 |
Molecular identification of dried squid merchandise bought in China utilizing DNA barcoding and SYBR inexperienced actual time PCR.
Dried squid merchandise are standard in China as a snack meals, aspect dishes, or refreshments, and the market enchantment will be mirrored by the excessive worth that often reaches 497 RMB per kg.
Nevertheless, the absence of harmonisation across the definition of squid, in addition to the issues with visible inspection for processed seafood merchandise, make different species substitution for dried squid merchandise a frequent prevalence.
The intention of the current examine was to use a DNA barcoding strategy for species identification of 48 dried squid merchandise collected from the most important on-line purchasing platform in China.
Furthermore, we additionally developed a novel SYBR inexperienced real-time PCR assay (simplex and duplex adopted by a melting curve evaluation) particular for Illex argentinus and Todarodes pacificus based mostly on cytochrome C oxidase subunit I (COI) gene.
Outcomes highlighted the profitable DNA extraction and PCR amplification of a 655 bp COI gene fragment from all merchandise.
A most similarity worth within the vary of 98-100% was obtained for all readable sequences utilizing the BOLD and BLAST public databases and 4 species (Dosidicus gigas, Uroteuthis edulis, I. argentinus, and T. pacificus) have been recognized.
The specificity of the designed primer units was confirmed towards 23 non-target species, and the newly developed strategies have been efficiently utilized to display I. argentinus and T. pacificus in dried squid merchandise.
Total, DNA barcoding is a strong device for seafood species identification and the novel methodology is efficient in screening I. argentinus and T. pacificus in meals merchandise.
PSMB8 antibody |
|||
| 70R-19589 | Fitzgerald | 50 ul | EUR 522 |
|
Description: Rabbit polyclonal PSMB8 antibody |
|||
PSMB8 Antibody |
|||
| 1-CSB-PA116429 | Cusabio |
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
|||
PSMB8 Antibody |
|||
| 1-CSB-PA018886GA01HU | Cusabio |
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
|||
PSMB8 Antibody |
|||
| 1-CSB-PA018886LA01HU | Cusabio |
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
|||
PSMB8 Antibody |
|||
| 1-CSB-PA775839 | Cusabio |
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
|||
PSMB8 Conjugated Antibody |
|||
| C43134 | SAB | 100ul | EUR 476.4 |
PSMB8 Polyclonal Antibody |
|||
| A73468 | EpiGentek |
|
|
PSMB8 Antibody, HRP conjugated |
|||
| 1-CSB-PA018886LB01HU | Cusabio |
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
|||
PSMB8 Antibody, FITC conjugated |
|||
| 1-CSB-PA018886LC01HU | Cusabio |
|
|
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
|||
PSMB8 Antibody, Biotin conjugated |
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| 1-CSB-PA018886LD01HU | Cusabio |
|
|
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
|||
Monoclonal PSMB8 Antibody, Clone: 1A5 |
|||
| AMM02864G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E |
|||
Psmb8/ Rat Psmb8 ELISA Kit |
|||
| ELI-15652r | Lifescience Market | 96 Tests | EUR 1063.2 |
Proteasome subunit beta type-8 (PSMB8) Antibody |
|||
| 20-abx211178 | Abbexa |
|
|
Proteasome subunit beta type-8 (PSMB8) Antibody |
|||
| 20-abx211851 | Abbexa |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| 20-abx141396 | Abbexa |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| 20-abx114776 | Abbexa |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| abx028154-400ul | Abbexa | 400 ul | EUR 627.6 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| abx028154-80l | Abbexa | 80 µl | EUR 343.2 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| 20-abx006453 | Abbexa |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|||
| abx011689-100ul | Abbexa | 100 ul | EUR 493.2 |
Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3 |
|||
| AMM03954G | Leading Biology | 0.1mg | EUR 580.8 |
|
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E |
|||
PSMB8 siRNA |
|||
| 20-abx930156 | Abbexa |
|
|
PSMB8 siRNA |
|||
| 20-abx930157 | Abbexa |
|
|
PSMB8 siRNA |
|||
| 20-abx904317 | Abbexa |
|
|
PSMB8 Rabbit pAb |
|||
| A7340-100ul | Abclonal | 100 ul | EUR 369.6 |
PSMB8 Rabbit pAb |
|||
| A7340-200ul | Abclonal | 200 ul | EUR 550.8 |
PSMB8 Rabbit pAb |
|||
| A7340-20ul | Abclonal | 20 ul | EUR 219.6 |
PSMB8 Rabbit pAb |
|||
| A7340-50ul | Abclonal | 50 ul | EUR 267.6 |
PSMB8 Blocking Peptide |
|||
| BF0434-BP | Affbiotech | 1mg | EUR 234 |
PSMB8 protein (His tag) |
|||
| 80R-2608 | Fitzgerald | 100 ug | EUR 386.4 |
|
Description: Purified recombinant PSMB8 protein |
|||
Canine PSMB8 ELISA KIT |
|||
| ELI-15651d | Lifescience Market | 96 Tests | EUR 1113.6 |
Rat PSMB8 shRNA Plasmid |
|||
| 20-abx984734 | Abbexa |
|
|
Human PSMB8 shRNA Plasmid |
|||
| 20-abx953843 | Abbexa |
|
|
Mouse PSMB8 shRNA Plasmid |
|||
| 20-abx971337 | Abbexa |
|
|
PSMB8 Recombinant Protein (Rat) |
|||
| RP222629 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Mouse) |
|||
| RP165287 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Human) |
|||
| RP085356 | ABM | 100 ug | Ask for price |
Psmb8 ORF Vector (Rat) (pORF) |
|||
| ORF074211 | ABM | 1.0 ug DNA | EUR 607.2 |
PSMB8 ORF Vector (Human) (pORF) |
|||
| ORF028453 | ABM | 1.0 ug DNA | EUR 486 |
Psmb8 ORF Vector (Mouse) (pORF) |
|||
| ORF055097 | ABM | 1.0 ug DNA | EUR 607.2 |
[KO Validated] PSMB8 Rabbit pAb |
|||
| A19933-100ul | Abclonal | 100 ul | EUR 492 |
[KO Validated] PSMB8 Rabbit pAb |
|||
| A19933-200ul | Abclonal | 200 ul | EUR 685.2 |
[KO Validated] PSMB8 Rabbit pAb |
|||
| A19933-20ul | Abclonal | 20 ul | EUR 265.2 |
[KO Validated] PSMB8 Rabbit pAb |
|||
| A19933-50ul | Abclonal | 50 ul | EUR 344.4 |
PSMB8 ELISA Kit (Dog) (OKEH03975) |
|||
| OKEH03975 | Aviva Systems Biology | 96 Wells | EUR 1012.8 |
|
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL |
|||
PSMB8 ELISA Kit (Human) (OKEH07770) |
|||
| OKEH07770 | Aviva Systems Biology | 96 Wells | EUR 1310.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL |
|||
PSMB8 ELISA Kit (Human) (OKCD02695) |
|||
| OKCD02695 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
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Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL |
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Psmb8 sgRNA CRISPR Lentivector set (Rat) |
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| K6921501 | ABM | 3 x 1.0 ug | EUR 406.8 |
PSMB8 sgRNA CRISPR Lentivector set (Human) |
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| K1740301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 sgRNA CRISPR Lentivector set (Mouse) |
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| K4425601 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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| TU167173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR GFP Stable Cell Line |
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| TU069046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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| TU266964 | ABM | 1.0 ml | Ask for price |
PSMB8 Protein Vector (Rat) (pPM-C-HA) |
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| PV296844 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-C-His) |
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| PV296842 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-N-His) |
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| PV296843 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPM-C-His) |
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| PV296845 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPM-C-HA) |
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| PV113812 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPM-C-HA) |
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| PV220388 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPB-C-His) |
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| PV113810 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPB-N-His) |
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| PV113811 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPM-C-His) |
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| PV113813 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPB-C-His) |
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| PV220386 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPB-N-His) |
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| PV220387 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPM-C-His) |
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| PV220389 | ABM | 500 ng | EUR 723.6 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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| TU117173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR Luciferase Stable Cell Line |
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| TU019046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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| TU216964 | ABM | 1.0 ml | Ask for price |
Human Proteasome subunit beta type-8 (PSMB8) |
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| 1-CSB-EP018886HU | Cusabio |
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Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli |
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Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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| K6921502 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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| K6921503 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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| K6921504 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K1740302 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2) |
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| K1740303 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3) |
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| K1740304 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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| K4425602 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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| K4425603 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4425604 | ABM | 1.0 ug DNA | EUR 184.8 |
Recombinant Human PSMB8 Protein, His, E.coli-1mg |
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| QP13190-1mg | EnQuireBio | 1mg | EUR 3308.4 |