
Pure Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Constructions and Conversion to Pharmacologically Essential Skeletons
The flexibility of the pure merchandise (2<i>S</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acids (<b>1</b> and <b>2</b>), remoted in giant quantities from tropical plant sources, has been demonstrated by the development of 3-substituted and three,4-disubstituted chiral pyrrolidine-2,5-diones.
- Absolutely the configurations of chiral pyrrolidine-2,5-diones have been ascertained utilizing chiroptical spectroscopic strategies and/or single-crystal XRD information. A mix of various response methods delivering a various matrix of fused heterocyclic ring methods is offered.
- The pyrrolo[2,1-<i>a</i>]isoquinoline alkaloid (+)-crispine A possesses a variety of pharmacological actions together with antidepressant, antiplatelet, antileukemic, and anticancer actions.
- The analogues of indolizino[8,7-<i>b</i>]indole alkaloids (+)- and (-)-harmicine present sturdy antileishmanial, antinociceptive, PDE5-inhibitory, antimalarial, and antiviral actions.
- The bicyclic furo[2,3-<i>b</i>]pyrrolo skeleton is current in lots of pure merchandise. Thus, the individuality of comparatively low cost, naturally occurring chiral 2-hydroxycitric acid lactones as chirons has been demonstrated by the development of some necessary molecular skeletons which are in any other case troublesome to synthesize.

allelebio
PSMB8 antibody |
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70R-19589 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal PSMB8 antibody |
PSMB8 Antibody |
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1-CSB-PA116429 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
PSMB8 Antibody |
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1-CSB-PA018886GA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
PSMB8 Antibody |
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1-CSB-PA018886LA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
PSMB8 Antibody |
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1-CSB-PA775839 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
PSMB8 Conjugated Antibody |
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C43134 | SAB | 100ul | EUR 476.4 |
PSMB8 Polyclonal Antibody |
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A73468 | EpiGentek |
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PSMB8 Antibody, HRP conjugated |
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1-CSB-PA018886LB01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
PSMB8 Antibody, FITC conjugated |
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1-CSB-PA018886LC01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
PSMB8 Antibody, Biotin conjugated |
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1-CSB-PA018886LD01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Monoclonal PSMB8 Antibody, Clone: 1A5 |
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AMM02864G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E |
Psmb8/ Rat Psmb8 ELISA Kit |
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ELI-15652r | Lifescience Market | 96 Tests | EUR 1063.2 |
Proteasome subunit beta type-8 (PSMB8) Antibody |
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20-abx211178 | Abbexa |
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Proteasome subunit beta type-8 (PSMB8) Antibody |
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20-abx211851 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx141396 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx114776 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx028154-400ul | Abbexa | 400 ul | EUR 627.6 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx028154-80l | Abbexa | 80 µl | EUR 343.2 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx006453 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx011689-100ul | Abbexa | 100 ul | EUR 493.2 |
Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3 |
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AMM03954G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E |
PSMB8 siRNA |
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20-abx930156 | Abbexa |
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PSMB8 siRNA |
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20-abx930157 | Abbexa |
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PSMB8 siRNA |
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20-abx904317 | Abbexa |
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PSMB8 Rabbit pAb |
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A7340-100ul | Abclonal | 100 ul | EUR 369.6 |
PSMB8 Rabbit pAb |
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A7340-200ul | Abclonal | 200 ul | EUR 550.8 |
PSMB8 Rabbit pAb |
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A7340-20ul | Abclonal | 20 ul | EUR 219.6 |
PSMB8 Rabbit pAb |
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A7340-50ul | Abclonal | 50 ul | EUR 267.6 |
PSMB8 Blocking Peptide |
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BF0434-BP | Affbiotech | 1mg | EUR 234 |
PSMB8 protein (His tag) |
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80R-2608 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Purified recombinant PSMB8 protein |
Canine PSMB8 ELISA KIT |
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ELI-15651d | Lifescience Market | 96 Tests | EUR 1113.6 |
Rat PSMB8 shRNA Plasmid |
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20-abx984734 | Abbexa |
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Human PSMB8 shRNA Plasmid |
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20-abx953843 | Abbexa |
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Mouse PSMB8 shRNA Plasmid |
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20-abx971337 | Abbexa |
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PSMB8 Recombinant Protein (Rat) |
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RP222629 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Mouse) |
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RP165287 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Human) |
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RP085356 | ABM | 100 ug | Ask for price |
Psmb8 ORF Vector (Rat) (pORF) |
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ORF074211 | ABM | 1.0 ug DNA | EUR 607.2 |
PSMB8 ORF Vector (Human) (pORF) |
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ORF028453 | ABM | 1.0 ug DNA | EUR 486 |
Psmb8 ORF Vector (Mouse) (pORF) |
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ORF055097 | ABM | 1.0 ug DNA | EUR 607.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-100ul | Abclonal | 100 ul | EUR 492 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-200ul | Abclonal | 200 ul | EUR 685.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-20ul | Abclonal | 20 ul | EUR 265.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-50ul | Abclonal | 50 ul | EUR 344.4 |
PSMB8 ELISA Kit (Dog) (OKEH03975) |
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OKEH03975 | Aviva Systems Biology | 96 Wells | EUR 1012.8 |
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL |
PSMB8 ELISA Kit (Human) (OKEH07770) |
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OKEH07770 | Aviva Systems Biology | 96 Wells | EUR 1310.4 |
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL |
PSMB8 ELISA Kit (Human) (OKCD02695) |
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OKCD02695 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL |
Psmb8 sgRNA CRISPR Lentivector set (Rat) |
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K6921501 | ABM | 3 x 1.0 ug | EUR 406.8 |
PSMB8 sgRNA CRISPR Lentivector set (Human) |
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K1740301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 sgRNA CRISPR Lentivector set (Mouse) |
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K4425601 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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TU167173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR GFP Stable Cell Line |
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TU069046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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TU266964 | ABM | 1.0 ml | Ask for price |
PSMB8 Protein Vector (Rat) (pPM-C-HA) |
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PV296844 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-C-His) |
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PV296842 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-N-His) |
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PV296843 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPM-C-His) |
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PV296845 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPM-C-HA) |
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PV113812 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPM-C-HA) |
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PV220388 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPB-C-His) |
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PV113810 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPB-N-His) |
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PV113811 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPM-C-His) |
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PV113813 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPB-C-His) |
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PV220386 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPB-N-His) |
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PV220387 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPM-C-His) |
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PV220389 | ABM | 500 ng | EUR 723.6 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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TU117173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR Luciferase Stable Cell Line |
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TU019046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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TU216964 | ABM | 1.0 ml | Ask for price |
Human Proteasome subunit beta type-8 (PSMB8) |
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1-CSB-EP018886HU | Cusabio |
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Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6921502 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6921503 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6921504 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1) |
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K1740302 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2) |
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K1740303 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3) |
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K1740304 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K4425602 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K4425603 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K4425604 | ABM | 1.0 ug DNA | EUR 184.8 |
Recombinant Human PSMB8 Protein, His, E.coli-1mg |
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QP13190-1mg | EnQuireBio | 1mg | EUR 3308.4 |
Synthesis and Spectroscopic Evaluation of Piperine- and Piperlongumine-Impressed Pure Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins
Impressed by the exceptional bioactivities exhibited by the pure merchandise, piperine and piperlongumine, we synthesised eight pure product-inspired analogues to additional examine their constructions.
For the primary time, we confirmed the construction of the important thing cyclised dihydropyrazolecarbothioamide piperine analogues together with the usage of two-dimensional (2D) <sup>15</sup>N-based spectroscopy nuclear magnetic resonance (NMR) spectroscopy. Prior investigations demonstrated promising outcomes from these scaffolds for the inhibition of inflammatory response by way of downregulation of the IL-1β and NF-κB pathway.
Nevertheless, the molecular interplay of those molecules with their protein targets stays unknown. Ab initio calculations revealed the digital density operate map of the molecules, exhibiting the results of structural modification within the digital construction.
Lastly, molecular interactions between the synthesized molecules and the proteins IL-1β and NF-κB had been achieved.
Docking outcomes confirmed that each one the analogues work together within the DNA binding web site of NF-κB with greater affinity in comparison with the pure merchandise and, except for <b>9a</b> and <b>9b,</b> have greater affinity than the pure merchandise for the binding web site of IL-1β. Specificity for the molecular recognition of <b>3a</b>, <b>3c</b> and <b>9b</b> with IL-1β by cation-π interactions was decided.
These outcomes revealed <b>3a</b>, <b>3c</b>, <b>4a</b>, <b>4c</b> and <b>10</b> as probably the most promising molecules to be evaluated as IL-1β and NF-κB inhibitors.
Key phrases: molecular docking; piperine; piperlongumine
First molecular detection of Coxiella burnetii in Brazilian artisanal cheese: a uncared for meals security hazard in ready-to-eat raw-milk product
Background: International publications on Q fever have elevated after the 2007 epidemic within the Netherlands. Nevertheless, the epidemiology of Q fever/coxiellosis in Brazil continues to be poorly understood. Accordingly, there have been few research investigating the presence of Coxiella burnetii in dairy merchandise world wide, particularly in Brazil, the place consumption of contemporary cheese comprised of raw-milk may be very excessive.
Goal: This research was a random survey to evaluate the prevalence of C. burnetii by PCR in conventional Minas artisanal cheese from the Serro microregion, Brazil, which is manufactured from bovine raw-milk.
Strategies: DNA extracted from 53 cheese samples had been analyzed by nested PCR with C. burnetii-specific primers and the merchandise confirmed by DNA sequencing.
Outcomes: Out of the 53 cheese samples 5 (9.43%) had been C. burnetii DNA-positive, every coming from one of many respective randomly chosen manufacturing agroindustries. Primarily based on our outcomes, it’s estimated that 1.62 tons/day of ready-to-eat cheese comprised of raw-milk from a complete of 16.2 tons produced every day within the research area are contaminated with C. burnetii.
Conclusion: To our data, that is the primary report of extremely heat-resistant zoonotic pathogen in raw-milk Brazilian artisanal cheese.
This meals security hazard has been fully uncared for in ready-to-eat raw-milk Brazilian artisanal cheese and will suggest potential threats to shoppers, since C. burnetii survives in artisanal cheese submitted to lengthy ripening intervals.
Thus, this work established random and consultant baseline prevalence of C. burnetii on this meals product in Brazil.
Additional epidemiological research, monitoring developments and setting management targets are warranted. Lastly, these outcomes level out the significance of together with C. burnetii in animal and public well being surveillance packages.
Key phrases: Brazil; Coxiella burnetii; Meals security; Minas artisanal cheese; Zoonosi
PSMB8 antibody |
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70R-19589 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal PSMB8 antibody |
PSMB8 Antibody |
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1-CSB-PA116429 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
PSMB8 Antibody |
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1-CSB-PA018886GA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
PSMB8 Antibody |
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1-CSB-PA018886LA01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
PSMB8 Antibody |
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1-CSB-PA775839 | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
PSMB8 Conjugated Antibody |
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C43134 | SAB | 100ul | EUR 476.4 |
PSMB8 Polyclonal Antibody |
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A73468 | EpiGentek |
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PSMB8 Antibody, HRP conjugated |
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1-CSB-PA018886LB01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
PSMB8 Antibody, FITC conjugated |
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1-CSB-PA018886LC01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
PSMB8 Antibody, Biotin conjugated |
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1-CSB-PA018886LD01HU | Cusabio |
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Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Monoclonal PSMB8 Antibody, Clone: 1A5 |
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AMM02864G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E |
Psmb8/ Rat Psmb8 ELISA Kit |
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ELI-15652r | Lifescience Market | 96 Tests | EUR 1063.2 |
Proteasome subunit beta type-8 (PSMB8) Antibody |
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20-abx211178 | Abbexa |
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Proteasome subunit beta type-8 (PSMB8) Antibody |
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20-abx211851 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx141396 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx114776 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx028154-400ul | Abbexa | 400 ul | EUR 627.6 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx028154-80l | Abbexa | 80 µl | EUR 343.2 |
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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20-abx006453 | Abbexa |
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Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
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abx011689-100ul | Abbexa | 100 ul | EUR 493.2 |
Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3 |
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AMM03954G | Leading Biology | 0.1mg | EUR 580.8 |
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E |
PSMB8 siRNA |
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20-abx930156 | Abbexa |
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PSMB8 siRNA |
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20-abx930157 | Abbexa |
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PSMB8 siRNA |
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20-abx904317 | Abbexa |
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PSMB8 Rabbit pAb |
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A7340-100ul | Abclonal | 100 ul | EUR 369.6 |
PSMB8 Rabbit pAb |
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A7340-200ul | Abclonal | 200 ul | EUR 550.8 |
PSMB8 Rabbit pAb |
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A7340-20ul | Abclonal | 20 ul | EUR 219.6 |
PSMB8 Rabbit pAb |
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A7340-50ul | Abclonal | 50 ul | EUR 267.6 |
PSMB8 Blocking Peptide |
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BF0434-BP | Affbiotech | 1mg | EUR 234 |
PSMB8 protein (His tag) |
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80R-2608 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Purified recombinant PSMB8 protein |
Canine PSMB8 ELISA KIT |
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ELI-15651d | Lifescience Market | 96 Tests | EUR 1113.6 |
Rat PSMB8 shRNA Plasmid |
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20-abx984734 | Abbexa |
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Human PSMB8 shRNA Plasmid |
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20-abx953843 | Abbexa |
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Mouse PSMB8 shRNA Plasmid |
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20-abx971337 | Abbexa |
|
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PSMB8 Recombinant Protein (Rat) |
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RP222629 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Mouse) |
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RP165287 | ABM | 100 ug | Ask for price |
PSMB8 Recombinant Protein (Human) |
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RP085356 | ABM | 100 ug | Ask for price |
Psmb8 ORF Vector (Rat) (pORF) |
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ORF074211 | ABM | 1.0 ug DNA | EUR 607.2 |
PSMB8 ORF Vector (Human) (pORF) |
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ORF028453 | ABM | 1.0 ug DNA | EUR 486 |
Psmb8 ORF Vector (Mouse) (pORF) |
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ORF055097 | ABM | 1.0 ug DNA | EUR 607.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-100ul | Abclonal | 100 ul | EUR 492 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-200ul | Abclonal | 200 ul | EUR 685.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-20ul | Abclonal | 20 ul | EUR 265.2 |
[KO Validated] PSMB8 Rabbit pAb |
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A19933-50ul | Abclonal | 50 ul | EUR 344.4 |
PSMB8 ELISA Kit (Dog) (OKEH03975) |
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OKEH03975 | Aviva Systems Biology | 96 Wells | EUR 1012.8 |
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL |
PSMB8 ELISA Kit (Human) (OKEH07770) |
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OKEH07770 | Aviva Systems Biology | 96 Wells | EUR 1310.4 |
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL |
PSMB8 ELISA Kit (Human) (OKCD02695) |
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OKCD02695 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL |
Psmb8 sgRNA CRISPR Lentivector set (Rat) |
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K6921501 | ABM | 3 x 1.0 ug | EUR 406.8 |
PSMB8 sgRNA CRISPR Lentivector set (Human) |
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K1740301 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 sgRNA CRISPR Lentivector set (Mouse) |
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K4425601 | ABM | 3 x 1.0 ug | EUR 406.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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TU167173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR GFP Stable Cell Line |
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TU069046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR GFP Stable Cell Line |
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TU266964 | ABM | 1.0 ml | Ask for price |
PSMB8 Protein Vector (Rat) (pPM-C-HA) |
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PV296844 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-C-His) |
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PV296842 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPB-N-His) |
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PV296843 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Rat) (pPM-C-His) |
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PV296845 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPM-C-HA) |
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PV113812 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPM-C-HA) |
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PV220388 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Human) (pPB-C-His) |
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PV113810 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPB-N-His) |
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PV113811 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Human) (pPM-C-His) |
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PV113813 | ABM | 500 ng | EUR 662.4 |
PSMB8 Protein Vector (Mouse) (pPB-C-His) |
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PV220386 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPB-N-His) |
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PV220387 | ABM | 500 ng | EUR 723.6 |
PSMB8 Protein Vector (Mouse) (pPM-C-His) |
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PV220389 | ABM | 500 ng | EUR 723.6 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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TU117173 | ABM | 1.0 ml | Ask for price |
PSMB8 3'UTR Luciferase Stable Cell Line |
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TU019046 | ABM | 1.0 ml | EUR 1672.8 |
Psmb8 3'UTR Luciferase Stable Cell Line |
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TU216964 | ABM | 1.0 ml | Ask for price |
Human Proteasome subunit beta type-8 (PSMB8) |
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1-CSB-EP018886HU | Cusabio |
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Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6921502 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6921503 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6921504 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1) |
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K1740302 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2) |
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K1740303 | ABM | 1.0 ug DNA | EUR 184.8 |
PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3) |
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K1740304 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K4425602 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K4425603 | ABM | 1.0 ug DNA | EUR 184.8 |
Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K4425604 | ABM | 1.0 ug DNA | EUR 184.8 |
Recombinant Human PSMB8 Protein, His, E.coli-1mg |
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QP13190-1mg | EnQuireBio | 1mg | EUR 3308.4 |