Molecular Structures and Conversion to Pharmacologically Important Skeletons

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allelebio

Pure Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Constructions and Conversion to Pharmacologically Essential Skeletons

The flexibility of the pure merchandise (2<i>S</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acids (<b>1</b> and <b>2</b>), remoted in giant quantities from tropical plant sources, has been demonstrated by the development of 3-substituted and three,4-disubstituted chiral pyrrolidine-2,5-diones.
  • Absolutely the configurations of chiral pyrrolidine-2,5-diones have been ascertained utilizing chiroptical spectroscopic strategies and/or single-crystal XRD information. A mix of various response methods delivering a various matrix of fused heterocyclic ring methods is offered.
  • The pyrrolo[2,1-<i>a</i>]isoquinoline alkaloid (+)-crispine A possesses a variety of pharmacological actions together with antidepressant, antiplatelet, antileukemic, and anticancer actions.
  • The analogues of indolizino[8,7-<i>b</i>]indole alkaloids (+)- and (-)-harmicine present sturdy antileishmanial, antinociceptive, PDE5-inhibitory, antimalarial, and antiviral actions.
  • The bicyclic furo[2,3-<i>b</i>]pyrrolo skeleton is current in lots of pure merchandise. Thus, the individuality of comparatively low cost, naturally occurring chiral 2-hydroxycitric acid lactones as chirons has been demonstrated by the development of some necessary molecular skeletons which are in any other case troublesome to synthesize.
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allelebio

PSMB8 Antibody
BF0434 200ul
EUR 540

PSMB8 Antibody
1-CSB-PA775839
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody
1-CSB-PA116429
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 Antibody
1-CSB-PA018886GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

PSMB8 Antibody
1-CSB-PA018886LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

PSMB8 Conjugated Antibody
C43134 100ul
EUR 476.4

Anti-PSMB8 antibody
STJ11100809 100 µl
EUR 495.6
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody
STJ29479 100 µl
EUR 332.4
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Polyclonal Antibody
A73468-050 50 ul
EUR 377.3

PSMB8 Polyclonal Antibody
A73468-100 100 ul
EUR 577.5

PSMB8 Polyclonal Antibody
A73468
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

Psmb8/ Rat Psmb8 ELISA Kit
ELI-15652r 96 Tests
EUR 1063.2

PSMB8 siRNA
20-abx904317
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA
20-abx930156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA
20-abx930157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

pOTB7-PSMB8
PVT18497 2 ug
EUR 277.2

PSMB8 Antibody, HRP conjugated
1-CSB-PA018886LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated
1-CSB-PA018886LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated
1-CSB-PA018886LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Rabbit pAb
A7340-100ul 100 ul
EUR 369.6

PSMB8 Rabbit pAb
A7340-200ul 200 ul
EUR 550.8

PSMB8 Rabbit pAb
A7340-20ul 20 ul
EUR 219.6

PSMB8 Rabbit pAb
A7340-50ul 50 ul
EUR 267.6

PSMB8 Blocking Peptide
BF0434-BP 1mg
EUR 234

anti-PSMB8 (1A5)
LF-MA30618 100 ul
EUR 632.4
Description: Mouse Monoclonal to PSMB8

Monoclonal PSMB8 Antibody, Clone: 1A5
AMM02864G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Anti-PSMB8 / LMP7 Monoclonal Antibody
M02188-2 100ug
EUR 476.4
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

PSMB8 protein (His tag)
80R-2608 100 ug
EUR 386.4
Description: Purified recombinant PSMB8 protein

Human PSMB8 shRNA Plasmid
20-abx953843
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat PSMB8 shRNA Plasmid
20-abx984734
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PSMB8 shRNA Plasmid
20-abx971337
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Canine PSMB8 ELISA KIT
ELI-15651d 96 Tests
EUR 1113.6

PSMB8 Recombinant Protein (Rat)
RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Human)
RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)
RP165287 100 ug Ask for price

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx141396
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx006453
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx114776
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx011689-100ul 100 ul
EUR 493.2

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-400ul 400 ul
EUR 627.6

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-80l 80 µl
EUR 343.2

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211178
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211851
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3
AMM03954G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

[KO Validated] PSMB8 Rabbit pAb
A19933-100ul 100 ul
EUR 492

[KO Validated] PSMB8 Rabbit pAb
A19933-200ul 200 ul
EUR 685.2

[KO Validated] PSMB8 Rabbit pAb
A19933-20ul 20 ul
EUR 265.2

[KO Validated] PSMB8 Rabbit pAb
A19933-50ul 50 ul
EUR 344.4

PSMB8 ELISA Kit (Human) (OKEH07770)
OKEH07770 96 Wells
EUR 1310.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 ORF Vector (Mouse) (pORF)
ORF055097 1.0 ug DNA
EUR 607.2

Psmb8 ORF Vector (Rat) (pORF)
ORF074211 1.0 ug DNA
EUR 607.2

PSMB8 ELISA Kit (Dog) (OKEH03975)
OKEH03975 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)
OKCD02695 96 Wells
EUR 950.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ORF Vector (Human) (pORF)
ORF028453 1.0 ug DNA
EUR 486

Psmb8 sgRNA CRISPR Lentivector set (Rat)
K6921501 3 x 1.0 ug
EUR 406.8

PSMB8 sgRNA CRISPR Lentivector set (Human)
K1740301 3 x 1.0 ug
EUR 406.8

Psmb8 sgRNA CRISPR Lentivector set (Mouse)
K4425601 3 x 1.0 ug
EUR 406.8

Human Proteasome subunit beta type-8 (PSMB8)
1-CSB-EP018886HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6921502 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6921503 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6921504 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)
K1740302 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)
K1740303 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)
K1740304 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4425602 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4425603 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4425604 1.0 ug DNA
EUR 184.8

PSMB8 Protein Vector (Human) (pPB-C-His)
PV113810 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPB-N-His)
PV113811 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPM-C-HA)
PV113812 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPM-C-His)
PV113813 500 ng
EUR 662.4

PSMB8 Protein Vector (Mouse) (pPB-C-His)
PV220386 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPB-N-His)
PV220387 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-HA)
PV220388 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-His)
PV220389 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-C-His)
PV296842 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-N-His)
PV296843 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPM-C-HA)
PV296844 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPM-C-His)
PV296845 500 ng
EUR 723.6
Synthesis and Spectroscopic Evaluation of Piperine- and Piperlongumine-Impressed Pure Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins

 

Impressed by the exceptional bioactivities exhibited by the pure merchandise, piperine and piperlongumine, we synthesised eight pure product-inspired analogues to additional examine their constructions.
For the primary time, we confirmed the construction of the important thing cyclised dihydropyrazolecarbothioamide piperine analogues together with the usage of two-dimensional (2D) <sup>15</sup>N-based spectroscopy nuclear magnetic resonance (NMR) spectroscopy. Prior investigations demonstrated promising outcomes from these scaffolds for the inhibition of inflammatory response by way of downregulation of the IL-1β and NF-κB pathway.
Nevertheless, the molecular interplay of those molecules with their protein targets stays unknown. Ab initio calculations revealed the digital density operate map of the molecules, exhibiting the results of structural modification within the digital construction.

Lastly, molecular interactions between the synthesized molecules and the proteins IL-1β and NF-κB had been achieved.

Docking outcomes confirmed that each one the analogues work together within the DNA binding web site of NF-κB with greater affinity in comparison with the pure merchandise and, except for <b>9a</b> and <b>9b,</b> have greater affinity than the pure merchandise for the binding web site of IL-1β. Specificity for the molecular recognition of <b>3a</b>, <b>3c</b> and <b>9b</b> with IL-1β by cation-π interactions was decided.
These outcomes revealed <b>3a</b>, <b>3c</b>, <b>4a</b>, <b>4c</b> and <b>10</b> as probably the most promising molecules to be evaluated as IL-1β and NF-κB inhibitors.
Key phrases: molecular docking; piperine; piperlongumine

First molecular detection of Coxiella burnetii in Brazilian artisanal cheese: a uncared for meals security hazard in ready-to-eat raw-milk product

Background: International publications on Q fever have elevated after the 2007 epidemic within the Netherlands. Nevertheless, the epidemiology of Q fever/coxiellosis in Brazil continues to be poorly understood. Accordingly, there have been few research investigating the presence of Coxiella burnetii in dairy merchandise world wide, particularly in Brazil, the place consumption of contemporary cheese comprised of raw-milk may be very excessive.
Goal: This research was a random survey to evaluate the prevalence of C. burnetii by PCR in conventional Minas artisanal cheese from the Serro microregion, Brazil, which is manufactured from bovine raw-milk.
Strategies: DNA extracted from 53 cheese samples had been analyzed by nested PCR with C. burnetii-specific primers and the merchandise confirmed by DNA sequencing.
Outcomes: Out of the 53 cheese samples 5 (9.43%) had been C. burnetii DNA-positive, every coming from one of many respective randomly chosen manufacturing agroindustries. Primarily based on our outcomes, it’s estimated that 1.62 tons/day of ready-to-eat cheese comprised of raw-milk from a complete of 16.2 tons produced every day within the research area are contaminated with C. burnetii.
Conclusion: To our data, that is the primary report of extremely heat-resistant zoonotic pathogen in raw-milk Brazilian artisanal cheese.
This meals security hazard has been fully uncared for in ready-to-eat raw-milk Brazilian artisanal cheese and will suggest potential threats to shoppers, since C. burnetii survives in artisanal cheese submitted to lengthy ripening intervals.
Thus, this work established random and consultant baseline prevalence of C. burnetii on this meals product in Brazil.
Additional epidemiological research, monitoring developments and setting management targets are warranted. Lastly, these outcomes level out the significance of together with C. burnetii in animal and public well being surveillance packages.
Key phrases: Brazil; Coxiella burnetii; Meals security; Minas artisanal cheese; Zoonosi

PSMB8 Antibody
BF0434 200ul
EUR 540

PSMB8 Antibody
1-CSB-PA775839
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody
1-CSB-PA116429
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 Antibody
1-CSB-PA018886GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

PSMB8 Antibody
1-CSB-PA018886LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

PSMB8 Conjugated Antibody
C43134 100ul
EUR 476.4

Anti-PSMB8 antibody
STJ11100809 100 µl
EUR 495.6
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody
STJ29479 100 µl
EUR 332.4
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Polyclonal Antibody
A73468-050 50 ul
EUR 377.3

PSMB8 Polyclonal Antibody
A73468-100 100 ul
EUR 577.5

PSMB8 Polyclonal Antibody
A73468
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

Psmb8/ Rat Psmb8 ELISA Kit
ELI-15652r 96 Tests
EUR 1063.2

PSMB8 siRNA
20-abx904317
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA
20-abx930156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA
20-abx930157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

pOTB7-PSMB8
PVT18497 2 ug
EUR 277.2

PSMB8 Antibody, HRP conjugated
1-CSB-PA018886LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated
1-CSB-PA018886LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated
1-CSB-PA018886LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Rabbit pAb
A7340-100ul 100 ul
EUR 369.6

PSMB8 Rabbit pAb
A7340-200ul 200 ul
EUR 550.8

PSMB8 Rabbit pAb
A7340-20ul 20 ul
EUR 219.6

PSMB8 Rabbit pAb
A7340-50ul 50 ul
EUR 267.6

PSMB8 Blocking Peptide
BF0434-BP 1mg
EUR 234

anti-PSMB8 (1A5)
LF-MA30618 100 ul
EUR 632.4
Description: Mouse Monoclonal to PSMB8

Monoclonal PSMB8 Antibody, Clone: 1A5
AMM02864G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Anti-PSMB8 / LMP7 Monoclonal Antibody
M02188-2 100ug
EUR 476.4
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

PSMB8 protein (His tag)
80R-2608 100 ug
EUR 386.4
Description: Purified recombinant PSMB8 protein

Human PSMB8 shRNA Plasmid
20-abx953843
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat PSMB8 shRNA Plasmid
20-abx984734
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PSMB8 shRNA Plasmid
20-abx971337
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Canine PSMB8 ELISA KIT
ELI-15651d 96 Tests
EUR 1113.6

PSMB8 Recombinant Protein (Rat)
RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Human)
RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)
RP165287 100 ug Ask for price

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx141396
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx006453
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx114776
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx011689-100ul 100 ul
EUR 493.2

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-400ul 400 ul
EUR 627.6

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-80l 80 µl
EUR 343.2

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211178
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211851
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3
AMM03954G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

[KO Validated] PSMB8 Rabbit pAb
A19933-100ul 100 ul
EUR 492

[KO Validated] PSMB8 Rabbit pAb
A19933-200ul 200 ul
EUR 685.2

[KO Validated] PSMB8 Rabbit pAb
A19933-20ul 20 ul
EUR 265.2

[KO Validated] PSMB8 Rabbit pAb
A19933-50ul 50 ul
EUR 344.4

PSMB8 ELISA Kit (Human) (OKEH07770)
OKEH07770 96 Wells
EUR 1310.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 ORF Vector (Mouse) (pORF)
ORF055097 1.0 ug DNA
EUR 607.2

Psmb8 ORF Vector (Rat) (pORF)
ORF074211 1.0 ug DNA
EUR 607.2

PSMB8 ELISA Kit (Dog) (OKEH03975)
OKEH03975 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)
OKCD02695 96 Wells
EUR 950.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ORF Vector (Human) (pORF)
ORF028453 1.0 ug DNA
EUR 486

Psmb8 sgRNA CRISPR Lentivector set (Rat)
K6921501 3 x 1.0 ug
EUR 406.8

PSMB8 sgRNA CRISPR Lentivector set (Human)
K1740301 3 x 1.0 ug
EUR 406.8

Psmb8 sgRNA CRISPR Lentivector set (Mouse)
K4425601 3 x 1.0 ug
EUR 406.8

Human Proteasome subunit beta type-8 (PSMB8)
1-CSB-EP018886HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6921502 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6921503 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6921504 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)
K1740302 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)
K1740303 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)
K1740304 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4425602 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4425603 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4425604 1.0 ug DNA
EUR 184.8

PSMB8 Protein Vector (Human) (pPB-C-His)
PV113810 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPB-N-His)
PV113811 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPM-C-HA)
PV113812 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPM-C-His)
PV113813 500 ng
EUR 662.4

PSMB8 Protein Vector (Mouse) (pPB-C-His)
PV220386 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPB-N-His)
PV220387 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-HA)
PV220388 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-His)
PV220389 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-C-His)
PV296842 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-N-His)
PV296843 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPM-C-HA)
PV296844 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPM-C-His)
PV296845 500 ng
EUR 723.6

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