Molecular Structures and Conversion to Pharmacologically Important Skeletons

allelebio

Pure Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Constructions and Conversion to Pharmacologically Essential Skeletons

The flexibility of the pure merchandise (2<i>S</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acids (<b>1</b> and <b>2</b>), remoted in giant quantities from tropical plant sources, has been demonstrated by the development of 3-substituted and three,4-disubstituted chiral pyrrolidine-2,5-diones.
  • Absolutely the configurations of chiral pyrrolidine-2,5-diones have been ascertained utilizing chiroptical spectroscopic strategies and/or single-crystal XRD information. A mix of various response methods delivering a various matrix of fused heterocyclic ring methods is offered.
  • The pyrrolo[2,1-<i>a</i>]isoquinoline alkaloid (+)-crispine A possesses a variety of pharmacological actions together with antidepressant, antiplatelet, antileukemic, and anticancer actions.
  • The analogues of indolizino[8,7-<i>b</i>]indole alkaloids (+)- and (-)-harmicine present sturdy antileishmanial, antinociceptive, PDE5-inhibitory, antimalarial, and antiviral actions.
  • The bicyclic furo[2,3-<i>b</i>]pyrrolo skeleton is current in lots of pure merchandise. Thus, the individuality of comparatively low cost, naturally occurring chiral 2-hydroxycitric acid lactones as chirons has been demonstrated by the development of some necessary molecular skeletons which are in any other case troublesome to synthesize.
allelebio

allelebio

PSMB8 antibody

22848-100ul 100ul
EUR 390

PSMB8 Antibody

43134-100ul 100ul
EUR 252

PSMB8 Antibody

BF0434 200ul
EUR 376
Description: PSMB8 antibody detects endogenous levels of total PSMB8.

PSMB8 antibody

70R-19589 50 ul
EUR 435
Description: Rabbit polyclonal PSMB8 antibody

PSMB8 antibody

70R-13550 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal PSMB8 antibody

Anti-PSMB8 antibody

STJ29479 100 µl
EUR 277
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody

STJ11100809 100 µl
EUR 413
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Conjugated Antibody

C43134 100ul
EUR 397

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 886

PSMB8 siRNA

20-abx930156
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx930157
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx904317
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

pOTB7-PSMB8

PVT18497 2 ug
EUR 231

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 308

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 459

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 183

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 223

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 195

anti-PSMB8 (1A5)

LF-MA30618 100 ul
EUR 527
Description: Mouse Monoclonal to PSMB8

Anti-PSMB8 / LMP7 Monoclonal Antibody

M02188-2 100ug
EUR 397
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 928

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 322
Description: Purified recombinant PSMB8 protein

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 411

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 523

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 286

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 410

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 571

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 221

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 287

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 844
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 792
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1092
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 506

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 405

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 506

PSMB8 sgRNA CRISPR Lentivector set (Human)

K1740301 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Rat)

K6921501 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Mouse)

K4425601 3 x 1.0 ug
EUR 339

Human Proteasome subunit beta type-8 (PSMB8)

1-CSB-EP018886HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)

K1740302 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)

K1740303 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)

K1740304 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6921502 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6921503 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6921504 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4425602 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4425603 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4425604 1.0 ug DNA
EUR 154

PSMB8 Protein Vector (Rat) (pPB-C-His)

PV296842 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPB-N-His)

PV296843 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-HA)

PV296844 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-His)

PV296845 500 ng
EUR 603

PSMB8 Protein Vector (Human) (pPB-C-His)

PV113810 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPB-N-His)

PV113811 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-HA)

PV113812 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-His)

PV113813 500 ng
EUR 552

Recombinant Human PSMB8 Protein, His, E.coli-1mg

QP13190-1mg 1mg
EUR 2757

Recombinant Human PSMB8 Protein, His, E.coli-20ug

QP13190-20ug 20ug
EUR 201

Recombinant Human PSMB8 Protein, His, E.coli-5ug

QP13190-5ug 5ug
EUR 155

PSMB8 Protein Vector (Mouse) (pPB-C-His)

PV220386 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPB-N-His)

PV220387 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-HA)

PV220388 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-His)

PV220389 500 ng
EUR 603
Synthesis and Spectroscopic Evaluation of Piperine- and Piperlongumine-Impressed Pure Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins

 

Impressed by the exceptional bioactivities exhibited by the pure merchandise, piperine and piperlongumine, we synthesised eight pure product-inspired analogues to additional examine their constructions.
For the primary time, we confirmed the construction of the important thing cyclised dihydropyrazolecarbothioamide piperine analogues together with the usage of two-dimensional (2D) <sup>15</sup>N-based spectroscopy nuclear magnetic resonance (NMR) spectroscopy. Prior investigations demonstrated promising outcomes from these scaffolds for the inhibition of inflammatory response by way of downregulation of the IL-1β and NF-κB pathway.
Nevertheless, the molecular interplay of those molecules with their protein targets stays unknown. Ab initio calculations revealed the digital density operate map of the molecules, exhibiting the results of structural modification within the digital construction.

Lastly, molecular interactions between the synthesized molecules and the proteins IL-1β and NF-κB had been achieved.

Docking outcomes confirmed that each one the analogues work together within the DNA binding web site of NF-κB with greater affinity in comparison with the pure merchandise and, except for <b>9a</b> and <b>9b,</b> have greater affinity than the pure merchandise for the binding web site of IL-1β. Specificity for the molecular recognition of <b>3a</b>, <b>3c</b> and <b>9b</b> with IL-1β by cation-π interactions was decided.
These outcomes revealed <b>3a</b>, <b>3c</b>, <b>4a</b>, <b>4c</b> and <b>10</b> as probably the most promising molecules to be evaluated as IL-1β and NF-κB inhibitors.
Key phrases: molecular docking; piperine; piperlongumine

First molecular detection of Coxiella burnetii in Brazilian artisanal cheese: a uncared for meals security hazard in ready-to-eat raw-milk product

Background: International publications on Q fever have elevated after the 2007 epidemic within the Netherlands. Nevertheless, the epidemiology of Q fever/coxiellosis in Brazil continues to be poorly understood. Accordingly, there have been few research investigating the presence of Coxiella burnetii in dairy merchandise world wide, particularly in Brazil, the place consumption of contemporary cheese comprised of raw-milk may be very excessive.
Goal: This research was a random survey to evaluate the prevalence of C. burnetii by PCR in conventional Minas artisanal cheese from the Serro microregion, Brazil, which is manufactured from bovine raw-milk.
Strategies: DNA extracted from 53 cheese samples had been analyzed by nested PCR with C. burnetii-specific primers and the merchandise confirmed by DNA sequencing.
Outcomes: Out of the 53 cheese samples 5 (9.43%) had been C. burnetii DNA-positive, every coming from one of many respective randomly chosen manufacturing agroindustries. Primarily based on our outcomes, it’s estimated that 1.62 tons/day of ready-to-eat cheese comprised of raw-milk from a complete of 16.2 tons produced every day within the research area are contaminated with C. burnetii.
Conclusion: To our data, that is the primary report of extremely heat-resistant zoonotic pathogen in raw-milk Brazilian artisanal cheese.
This meals security hazard has been fully uncared for in ready-to-eat raw-milk Brazilian artisanal cheese and will suggest potential threats to shoppers, since C. burnetii survives in artisanal cheese submitted to lengthy ripening intervals.
Thus, this work established random and consultant baseline prevalence of C. burnetii on this meals product in Brazil.
Additional epidemiological research, monitoring developments and setting management targets are warranted. Lastly, these outcomes level out the significance of together with C. burnetii in animal and public well being surveillance packages.
Key phrases: Brazil; Coxiella burnetii; Meals security; Minas artisanal cheese; Zoonosi

PSMB8 antibody

22848-100ul 100ul
EUR 390

PSMB8 Antibody

43134-100ul 100ul
EUR 252

PSMB8 Antibody

BF0434 200ul
EUR 376
Description: PSMB8 antibody detects endogenous levels of total PSMB8.

PSMB8 antibody

70R-19589 50 ul
EUR 435
Description: Rabbit polyclonal PSMB8 antibody

PSMB8 antibody

70R-13550 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal PSMB8 antibody

Anti-PSMB8 antibody

STJ29479 100 µl
EUR 277
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody

STJ11100809 100 µl
EUR 413
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Conjugated Antibody

C43134 100ul
EUR 397

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 886

PSMB8 siRNA

20-abx930156
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx930157
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx904317
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

pOTB7-PSMB8

PVT18497 2 ug
EUR 231

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 308

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 459

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 183

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 223

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 195

anti-PSMB8 (1A5)

LF-MA30618 100 ul
EUR 527
Description: Mouse Monoclonal to PSMB8

Anti-PSMB8 / LMP7 Monoclonal Antibody

M02188-2 100ug
EUR 397
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 928

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 322
Description: Purified recombinant PSMB8 protein

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 411

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 523

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 286

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 410

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 571

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 221

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 287

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 844
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 792
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1092
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 506

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 405

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 506

PSMB8 sgRNA CRISPR Lentivector set (Human)

K1740301 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Rat)

K6921501 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Mouse)

K4425601 3 x 1.0 ug
EUR 339

Human Proteasome subunit beta type-8 (PSMB8)

1-CSB-EP018886HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)

K1740302 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)

K1740303 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)

K1740304 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6921502 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6921503 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6921504 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4425602 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4425603 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4425604 1.0 ug DNA
EUR 154

PSMB8 Protein Vector (Rat) (pPB-C-His)

PV296842 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPB-N-His)

PV296843 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-HA)

PV296844 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-His)

PV296845 500 ng
EUR 603

PSMB8 Protein Vector (Human) (pPB-C-His)

PV113810 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPB-N-His)

PV113811 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-HA)

PV113812 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-His)

PV113813 500 ng
EUR 552

Recombinant Human PSMB8 Protein, His, E.coli-1mg

QP13190-1mg 1mg
EUR 2757

Recombinant Human PSMB8 Protein, His, E.coli-20ug

QP13190-20ug 20ug
EUR 201

Recombinant Human PSMB8 Protein, His, E.coli-5ug

QP13190-5ug 5ug
EUR 155

PSMB8 Protein Vector (Mouse) (pPB-C-His)

PV220386 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPB-N-His)

PV220387 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-HA)

PV220388 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-His)

PV220389 500 ng
EUR 603

Leave a Reply

Your email address will not be published.