The Burden of JAK2V617F Mutated Allele in Turkish Patients With Myeloproliferative Neoplasms.

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The Burden of JAK2V617F Mutated Allele in Turkish Patients With Myeloproliferative Neoplasms.

BACKGROUND
Studies on the impact of the load on the allele JAK2V617F and clinical phenotypic traits in Philadelphia-negative myeloproliferative neoplasms (MPNs Ph-negative) have reported variable results. We aimed to analyze the association JAK2V617F mutated allele burden with the characteristics of laboratory and clinical phenotype in patients Turkey (107 essential thrombocythemia (ET) and 77 primary myelofibrosis (PMF)).

METHOD
Peripheral blood samples from 184 patients with Ph-negative MPNs analyzed for JAK2V617F allele status and load. MutaScreen JAK2 assay (Ipsogen, Luminy Biotech, Marseille, France) was used to detect the status JAK2V617F and JAK2V617F quantitative allele burden in genomic DNA using the TaqMan allelic discrimination.


RESULTS
Frequency JAK2V617F-positive patients with a high mutation load (allele burden >> 50%) higher in comparison with ET PMF (23.4% and 4.7%, respectively; P = 0.001). We found a significant association between patients ET with JAK2V617F high-allele burden and low hemoglobin (Hb) and hematocrit (Ht), LDH levels were higher and massive splenomegaly more common (P = 0.001, P = 0.001, P = 0.012 and P = 0.015, respectively). ET patients with a high mutation load shown a higher prevalence of bleeding compared with a low mutation load and the wild-type mutation status (P = 0.003). DVT level was significantly higher in patients with ET with a mutant allele burden at the top compared to reduce by half and the wild-type (P = 0.029). We observed a significant association between patients PMF with high JAK2V617F allele burden and higher hemoglobin, hematocrit level and the number of leukocytes (P = 0.003, P = 0.021 and P = 0.001, respectively).


CONCLUSION
Our study shows JAK2V617F load allele correlated with clinical features in ET and PMF. We conclude JAK2V617F quantification of mutations contributing to the examination of Ph-negative MPNs.

The Burden of JAK2V617F Mutated Allele in Turkish Patients With Myeloproliferative Neoplasms.
The Burden of JAK2V617F Mutated Allele in Turkish Patients With Myeloproliferative Neoplasms.

[The relationship between vitamin D receptor gene polymorphism and chronic periodontitis].

OBJECTIVE
To investigate the relationship between vitamin D receptor (VDR) gene polymorphism and chronic periodontitis (CP).


METHOD
buccal swabs of 105 patients with mild CP / mode-level and 85 severe CP collected, this DNA was extracted from buccal swabs using DNA Swab Kit TIANamp [TIANGEN Biotech (Beijing) CO.Ltd]. VDR rs1544410 and rs731236 were genotyped by Sequenom MassARRAY system (Shanghai Benegene Biotechnology Co. Ltd.), which is based on MALDI-TOF technology (matrix-assisted laser desorption ionization time-of-flight). Genotype distribution and allele frequency was analyzed.


RESULTS
Frequency of rs1544410 A allele and AA + AG genotype were significantly higher in CP severe than in mild / moderate CP of all patients and female patients respectively (all patients: P = 0.006, 0.007, whereas female patients: P = 0.001, 0.001 ). Frequency of rs731236 C allele and CC + CT genotype was significantly higher in CP severe than in mild / moderate CP of all patients and female patients respectively (all patients: P = 0.003, 0.004, whereas female patients: P <0.001, < 0.001).


CONCLUSION
VDR gene polymorphism rs731236 and rs1544410 may be associated with severe CP in the Han Chinese population.
the level of expression of hemocyanin (LvHc), activating transcription factor 4 (LvAtf4), glutathione S-transferase (LvGst), caspase 2 (LvCasp2) and factor anti-lipopolysaccharide (LvAlf) examined in hepatopancreas of Pacific white shrimp Litopenaeus vannamei adolescents exposed to lethal concentration ammonia-N (32.15 mg / l).

p38
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p38 Rabbit pAb
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anti-Crk p38
YF-PA11088 50 ul
EUR 435.6
Description: Mouse polyclonal to Crk p38

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YF-PA11089 50 ug
EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11090 100 ug
EUR 483.6
Description: Rabbit polyclonal to Crk p38

anti-Crk p38
YF-PA23509 50 ul
EUR 400.8
Description: Mouse polyclonal to Crk p38

p38 beta, Active
7763-100 each
EUR 5214

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7763-5 each
EUR 444

p38 beta protein
30R-2875 5 ug
EUR 425
Description: Purified recombinant Human p38 beta protein

Crk p38 Antibody
AF6323 200ul
EUR 420

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AF6323-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Crk p38 Antibody
AF6323-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

p38 (C20) Antibody
MBS440021-02mg 0.2mg
EUR 285

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MBS440021-5x02mg 5x0.2mg
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MBS805179-01mL 0.1mL
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MBS805299-01mL 0.1mL
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EUR 1535

p38 Hog Antibody
P9809 100ug
EUR 259

p38 Antibody: APC
SPC-172D-APC 0.1ml
EUR 197.4
Description: Rabbit Anti-Human p38 Polyclonal

p38 Antibody: HRP
SPC-172D-HRP 0.1ml
EUR 189
Description: Rabbit Anti-Human p38 Polyclonal

The level of expression of all transcripts except LvAlf significantly greater (P <0.05) in tolerant shrimp (Lv-AT; N = 30) who survived to 72 hours post-treatment (hpt) than in the susceptible shrimp (Lv-AS24 and Lv – AS72; N = 45 and 15), who died within 24 hours, or between 24 and 72 hpt, respectively.

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