Molecular Structures and Conversion to Pharmacologically Important Skeletons

Pure Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Constructions and Conversion to Pharmacologically Essential Skeletons The flexibility of the pure merchandise (2<i>S</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acids (<b>1</b> and <b>2</b>), remoted in giant quantities from tropical plant… Read more »

Unveiling the molecular mechanisms underpinning biorecognition

Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products. Serum levels of early-glycated albumin are significantly increased in patients with diabetes mellitus and may… Read more »

Molecular epidemiology of Usher syndrome in Italy.

OBJECTIVEUsher syndrome is an autosomal recessive disorder characterized by hearing and vision loss. Usher syndrome is clinically divided into three subclasses (type 1, type 2 and type 3), which differ… Read more »

The clinical effect of homozygous ABCA4 alleles in 18 patients.

OBJECTIVETo illustrate the phenotypic presentation of a group of individuals with the homozygous variant ABCA4 related diseases. METHODretrospective case series. METHODEighteen of the affected individuals from 13 families ascertained from… Read more »

The Burden of JAK2V617F Mutated Allele in Turkish Patients With Myeloproliferative Neoplasms.

BACKGROUNDStudies on the impact of the load on the allele JAK2V617F and clinical phenotypic traits in Philadelphia-negative myeloproliferative neoplasms (MPNs Ph-negative) have reported variable results. We aimed to analyze the… Read more »