Pure Product-Derived Chiral Pyrrolidine-2,5-diones, Their Molecular Constructions and Conversion to Pharmacologically Essential Skeletons The flexibility of the pure merchandise (2<i>S</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acids (<b>1</b> and <b>2</b>), remoted in giant quantities from tropical plant… Read more »
Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products. Serum levels of early-glycated albumin are significantly increased in patients with diabetes mellitus and may… Read more »
OBJECTIVEUsher syndrome is an autosomal recessive disorder characterized by hearing and vision loss. Usher syndrome is clinically divided into three subclasses (type 1, type 2 and type 3), which differ… Read more »
OBJECTIVETo illustrate the phenotypic presentation of a group of individuals with the homozygous variant ABCA4 related diseases. METHODretrospective case series. METHODEighteen of the affected individuals from 13 families ascertained from… Read more »
BACKGROUNDStudies on the impact of the load on the allele JAK2V617F and clinical phenotypic traits in Philadelphia-negative myeloproliferative neoplasms (MPNs Ph-negative) have reported variable results. We aimed to analyze the… Read more »
Until now, pyridoxine (PN), the most common vitamer B6 comes to animals and humans, are chemically synthesized for commercial purposes. Thus, the development of microbial fermentation process is very attractive… Read more »
Improve fruit quality has been a major goal in plant breeding. Direct approaches to address the nature of the fruit quality specifically related to consumer preferences and environmentally friendly, such… Read more »
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